IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10

• Published in: Frontiers in immunology Vol. 10; p. 3059
• Main Authors: Fonseca, Miriam M, Davoli-Ferreira, Marcela, Santa-Cecília, Flávia, Guimarães, Rafaela M, Oliveira, Francisco F B, Kusuda, Ricardo, Ferreira, David W, Alves-Filho, José C, Cunha, Fernando Q, Cunha, Thiago M
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.01.2020
• Subjects: cytokines; glial cells; IL-10; IL-27; Immunology; macrophages; neuropathic pain; IL-27; glial cells; macrophages; neuropathic pain; cytokines; IL-10

Neuroimmune-glia interactions have been implicated in the development of neuropathic pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory conditions of the central nervous system. Thus, we hypothesized that IL-27 would participate in the neuropathic pain proce...