Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats

• Published in: Brain research. Developmental brain research Vol. 153; no. 2; pp. 175 - 187
• Main Authors: Collins, Stephanie L., Montano, Raquel, Izenwasser, Sari
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.11.2004
• Subjects: Adolescence; Amphetamine; Amphetamine - pharmacology; Animals; Central Nervous System Stimulants - pharmacology; Dose-Response Relationship, Drug; Drug Synergism; Female; Locomotor activity; Male; Motor Activity - drug effects; Nicotine; Nicotine - pharmacology; Nicotinic Agonists - pharmacology; Rats; Sensitization; Sex Characteristics; Stimulation, Chemical; Adolescence; Sensitization; Amphetamine; Neural basis of behavior; Locomotor activity; Nicotine

Nicotine is a popular addictive drug used among the adolescent population, and it has long been questioned whether nicotine use in adolescence may lead to the use of other psychostimulant drugs. It is not fully understood, however, how nicotine alters behavior and brain neurochemistry in the adolesc...