PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

• Published in: Frontiers in immunology Vol. 8; p. 1597
• Main Authors: Xu-Monette, Zijun Y., Zhang, Mingzhi, Li, Jianyong, Young, Ken H.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.12.2017
• Subjects: biomarker; immune checkpoint blockade; Immunology; MSI; PD-1; PD-L1; TMB; MSI; PD-L1; TMB; combination immunotherapy; resistance mechanism; biomarker; PD-1; immune checkpoint blockade

PD-1-PD-L1 interaction is known to drive T cell dysfunction, which can be blocked by anti-PD-1/PD-L1 antibodies. However, studies have also shown that the function of the PD-1-PD-L1 axis is affected by the complex immunologic regulation network, and some CD8 T cells can enter an irreversible dysfunc...