Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects

• Published in: Journal of psychopharmacology (Oxford) Vol. 34; no. 3; p. 358
• Main Authors: Punchaichira, Toyanji J, Mukhopadhyay, Anirban, Kukshal, Prachi, Bhatia, Triptish, Deshpande, Smita N, Thelma, B K
• Format: Journal Article
• Language: English
• Published: United States 01.03.2020
• Subjects: Adult; Case-Control Studies; Cognition; Dopamine beta-Hydroxylase - genetics; Endophenotypes; Female; Genetic Association Studies; Haplotypes; Humans; Male; Polymorphism, Genetic - genetics; Schizophrenia - genetics; Schizophrenic Psychology; Tardive Dyskinesia - genetics; Young Adult; cognition; dual luciferase reporter assay; regulatory variants; 19bp Ins/Del (rs141116007); Dopamine-β-hydroxylase; rs1989787; schizophrenia; rs1611115; genetic interaction; tardive dyskinesia

Dopamine-β-hydroxylase (DBH, EC 1.14.17.1), which converts dopamine to norepinephrine, is a candidate gene in neuropsychiatric diseases. To assess the effect of regulatory variants in on schizophrenia and its endophenotypes -cognition and tardive dyskinesia. We tested association of functional varia...