A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

• Published in: Cancer cell Vol. 25; no. 2; pp. 166 - 180
• Main Authors: Jiao, Shi, Wang, Huizhen, Shi, Zhubing, Dong, Aimei, Zhang, Wenjing, Song, Xiaomin, He, Feng, Wang, Yicui, Zhang, Zhenzhen, Wang, Wenjia, Wang, Xin, Guo, Tong, Li, Peixue, Zhao, Yun, Ji, Hongbin, Zhang, Lei, Zhou, Zhaocai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.02.2014
• Subjects: Animals; Antimetabolites, Antineoplastic - pharmacology; Case-Control Studies; Cell Survival; DNA-Binding Proteins - metabolism; Female; Fluorouracil - pharmacology; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Middle Aged; Molecular Mimicry; Muscle Proteins - metabolism; Neoplasm Invasiveness; Neoplasm Staging; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Peptide Fragments - pharmacology; Protein Conformation; Stomach - metabolism; Stomach - pathology; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - prevention & control; Tissue Array Analysis; Transcription Factors - antagonists & inhibitors; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism

The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppress...