A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppress...

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Published in	Cancer cell Vol. 25; no. 2; pp. 166 - 180
Main Authors	Jiao, Shi, Wang, Huizhen, Shi, Zhubing, Dong, Aimei, Zhang, Wenjing, Song, Xiaomin, He, Feng, Wang, Yicui, Zhang, Zhenzhen, Wang, Wenjia, Wang, Xin, Guo, Tong, Li, Peixue, Zhao, Yun, Ji, Hongbin, Zhang, Lei, Zhou, Zhaocai
Format	Journal Article
Language	English
Published	United States Elsevier Inc 10.02.2014
Subjects	Animals Antimetabolites, Antineoplastic - pharmacology Case-Control Studies Cell Survival DNA-Binding Proteins - metabolism Female Fluorouracil - pharmacology Humans Immunoenzyme Techniques Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred ICR Middle Aged Molecular Mimicry Muscle Proteins - metabolism Neoplasm Invasiveness Neoplasm Staging Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Peptide Fragments - pharmacology Protein Conformation Stomach - metabolism Stomach - pathology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - prevention & control Tissue Array Analysis Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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Abstract	The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4’s tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers. [Display omitted] •VGLL4 is a potential tumor suppressor and prognostic marker in gastric cancer•VGLL4, via its tandem TDU domain, directly competes with YAP for binding to TEADs•A peptide functionally mimicking VGLL4 potently inhibits gastric cancer growth•Ratio of YAP to VGLL4 could serve as a prognostic marker for personalized therapy Jiao et al. show that VGLL4 competes with YAP for binding to TEAD coactivators and, in this manner, VGLL4 acts as a tumor suppressor in gastric cancer. The authors utilize this knowledge to devise a VGLL4 peptide mimic that inhibits YAP oncogenic activity and acts therapeutically against gastric cancer.
AbstractList	The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4’s tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers. [Display omitted] •VGLL4 is a potential tumor suppressor and prognostic marker in gastric cancer•VGLL4, via its tandem TDU domain, directly competes with YAP for binding to TEADs•A peptide functionally mimicking VGLL4 potently inhibits gastric cancer growth•Ratio of YAP to VGLL4 could serve as a prognostic marker for personalized therapy Jiao et al. show that VGLL4 competes with YAP for binding to TEAD coactivators and, in this manner, VGLL4 acts as a tumor suppressor in gastric cancer. The authors utilize this knowledge to devise a VGLL4 peptide mimic that inhibits YAP oncogenic activity and acts therapeutically against gastric cancer. The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4's tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers.The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4's tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers. The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4's tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers.
Author	Wang, Yicui Wang, Huizhen Wang, Xin Wang, Wenjia Zhao, Yun He, Feng Zhang, Wenjing Zhang, Lei Shi, Zhubing Guo, Tong Song, Xiaomin Zhang, Zhenzhen Zhou, Zhaocai Jiao, Shi Ji, Hongbin Dong, Aimei Li, Peixue
Author_xml	– sequence: 1 givenname: Shi surname: Jiao fullname: Jiao, Shi organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 2 givenname: Huizhen surname: Wang fullname: Wang, Huizhen organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 3 givenname: Zhubing surname: Shi fullname: Shi, Zhubing organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 4 givenname: Aimei surname: Dong fullname: Dong, Aimei organization: Department of Gastroenterology and Internal Medicine, Nanjing Xiaguan Hospital, Nanjing, Jiangsu 210085, China – sequence: 5 givenname: Wenjing surname: Zhang fullname: Zhang, Wenjing organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 6 givenname: Xiaomin surname: Song fullname: Song, Xiaomin organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 7 givenname: Feng surname: He fullname: He, Feng organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 8 givenname: Yicui surname: Wang fullname: Wang, Yicui organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 9 givenname: Zhenzhen surname: Zhang fullname: Zhang, Zhenzhen organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 10 givenname: Wenjia surname: Wang fullname: Wang, Wenjia organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 11 givenname: Xin surname: Wang fullname: Wang, Xin organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 12 givenname: Tong surname: Guo fullname: Guo, Tong organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 13 givenname: Peixue surname: Li fullname: Li, Peixue organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 14 givenname: Yun surname: Zhao fullname: Zhao, Yun organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 15 givenname: Hongbin surname: Ji fullname: Ji, Hongbin email: hbji@sibcb.ac.cn organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 16 givenname: Lei surname: Zhang fullname: Zhang, Lei email: rayzhang@sibcb.ac.cn organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China – sequence: 17 givenname: Zhaocai surname: Zhou fullname: Zhou, Zhaocai email: zczhou@sibcb.ac.cn organization: National Center for Protein Science Shanghai, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24525233$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/j.devcel.2010.09.009 10.4161/cc.11.6.19453 10.1038/cr.2013.120 10.1016/j.devcel.2013.04.021 10.1159/000121000 10.1016/j.str.2012.04.004 10.1016/j.devcel.2010.03.007 10.1186/1476-4598-10-122 10.1194/jlr.M032755 10.1016/j.cell.2006.05.030 10.1016/j.cub.2008.02.034 10.1016/j.devcel.2008.01.006 10.1101/gad.1664408 10.1242/dev.045500 10.1073/pnas.1202490109 10.1111/j.1349-7006.2007.00392.x 10.1186/1755-1536-5-S1-S8 10.1016/j.molcel.2013.05.013 10.1074/jbc.M400154200 10.1038/onc.2011.8 10.1016/j.ccr.2009.09.026 10.1038/nrc2070 10.1158/1078-0432.CCR-04-2639 10.1177/039463201202500416 10.1007/s13238-012-2913-9 10.1016/j.devcel.2009.12.011 10.1038/cr.2014.10 10.1101/gad.1602907 10.1101/gad.1978810 10.1093/nar/gkh248 10.1053/j.gastro.2005.03.037 10.1101/gad.196501.112 10.1074/jbc.M206858200 10.1387/ijdb.103080cf 10.1046/j.1440-1746.2002.02684.x 10.1016/j.semcdb.2012.05.002 10.1046/j.1523-5378.1998.08017.x 10.1016/j.cell.2005.06.007 10.1101/gad.1909210 10.1016/j.humpath.2008.04.012 10.1101/gad.1824509 10.1002/jcp.22435 10.1016/j.cell.2012.11.027 10.1016/j.devcel.2008.01.007 10.1038/nature11693 10.1126/science.1238016 10.1186/bcr3349 10.1242/dev.126.21.4807 10.3346/jkms.2011.26.5.647 10.1074/jbc.M111.327767 10.1016/j.devcel.2010.09.011 10.7314/APJCP.2013.14.9.5199 10.1016/j.ccr.2008.02.011 10.1101/gad.192856.112 10.1002/jso.21984 10.3748/wjg.15.4055 10.1038/ncb1339
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References	Da, Xin, Zhao, Luo (bib9) 2009; 15 Zhou, Li, Zhang, Zhao, Zhang, Xue, Yang, Tian (bib56) 2013; 14 Cai, Zhang, Zheng, de Wilde, Maitra, Pan (bib4) 2010; 24 Houghton, Wang (bib23) 2005; 128 Jacobson, Cunningham (bib25) 2012; 5 Koontz, Liu-Chittenden, Yin, Zheng, Yu, Huang, Chen, Wu, Pan (bib30) 2013; 25 Huang, Wu, Barrera, Matthews, Pan (bib24) 2005; 122 Maeda, Chapman, Stewart (bib33) 2002; 277 Zhou, Conrad, Xia, Park, Payer, Yin, Lauwers, Thasler, Lee, Avruch, Bardeesy (bib55) 2009; 16 Chen, Qin, Deng, Avruch, Zhou (bib7) 2012; 3 Vaudin, Delanoue, Davidson, Silber, Zider (bib44) 1999; 126 Barry, Morikawa, Butler, Shrestha, de la Rosa, Yan, Fuchs, Magness, Smits, Ogino (bib3) 2013; 493 Stanger (bib39) 2012; 26 Pobbati, Chan, Lee, Song, Hong (bib38) 2012; 20 Halperin, Pan, Lusis, Tontonoz (bib18) 2013; 54 Wang, Park, Wei, Rajurkar, Cotton, Fan, Lewis, Ji, Mao (bib45) 2013; 51 Azzolin, Zanconato, Bresolin, Forcato, Basso, Bicciato, Cordenonsi, Piccolo (bib2) 2012; 151 Konsavage, Kyler, Rennoll, Jin, Yochum (bib29) 2012; 287 Jukam, Xie, Rister, Terrell, Charlton-Perkins, Pistillo, Gebelein, Desplan, Cook (bib27) 2013; 342 Cui, Han, Peng, Chen, Luan, Han, Xu, Guo (bib8) 2012; 25 Steinhardt, Gayyed, Klein, Dong, Maitra, Pan, Montgomery, Anders (bib40) 2008; 39 Danon, Eaton (bib10) 1998; 3 Varelas, Miller, Sopko, Song, Gregorieff, Fellouse, Sakuma, Pawson, Hunziker, McNeill (bib43) 2010; 18 Genevet, Wehr, Brain, Thompson, Tapon (bib13) 2010; 18 Hergovich (bib22) 2012; 14 Zhao, Li, Lei, Guan (bib53) 2010; 24 Lin, Zuon, Chang, Chen, Chen, Lin, Wang, Jeng, Chang, Lee (bib31) 2005; 11 Avruch, Zhou, Bardeesy (bib1) 2012; 11 Halder, Johnson (bib17) 2011; 138 Wu, Liu, Zheng, Dong, Pan (bib46) 2008; 14 Zhang, George, Deb, Degoutin, Takano, Fox, Bowtell, Harvey (bib50) 2011; 30 Takaishi, Wang (bib42) 2007; 98 Pan (bib37) 2010; 19 Sudol, Shields, Farooq (bib41) 2012; 23 Zhao, Ye, Yu, Li, Li, Li, Yu, Lin, Wang, Chinnaiyan (bib52) 2008; 22 Zhang, Gao, Li, Shi, Guo, Li, Han, Feng, Zheng, Wang (bib57) 2014 Maeta, Osaki, Shomori, Inaba, Kidani, Ikeguchi, Ito (bib34) 2007; 73 Zhao, Li, Wang, Wang (bib54) 2011; 104 Hamaratoglu, Willecke, Kango-Singh, Nolo, Hyun, Tao, Jafar-Nejad, Halder (bib19) 2006; 8 Mann, Ward, Yew, Kovochich, Dawson, Black, Brett, Sheetz, Dupuy, Chang (bib35) 2012; 109 Fernandez, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney (bib12) 2009; 23 Goulev, Fauny, Gonzalez-Marti, Flagiello, Silber, Zider (bib14) 2008; 18 Guo, Lu, Li, Yin, Lv, Zhang, Wang, Zhou, Ji, Zhao, Zhang (bib16) 2013; 23 Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon (bib47) 2006; 125 Zeng, Hong (bib48) 2008; 13 Harvey, Tapon (bib21) 2007; 7 Faucheux, Naye, Tréguer, Fédou, Thiébaud, Théze (bib11) 2010; 54 Liu-Chittenden, Huang, Shim, Chen, Lee, Anders, Liu, Pan (bib32) 2012; 26 Günther, Mielcarek, Krüger, Braun (bib15) 2004; 32 Kang, Lee, Kim, Lee, Lee, Park, Kim, Jung, Song (bib28) 2011; 26 Han, Kim, Joo, Hahm, Lee, Cho, Kim, Kim (bib20) 2002; 17 Neto-Silva, de Beco, Johnston (bib36) 2010; 19 Chan, Lim, Chen, Chong, Huang, Song, Hong (bib5) 2011; 226 Zhang, Ren, Zhang, Chen, Wang, Jiang (bib49) 2008; 14 Chen, Mullett, Stewart (bib6) 2004; 279 Zhao, Wei, Li, Udan, Yang, Kim, Xie, Ikenoue, Yu, Li (bib51) 2007; 21 Jiang, Lv, Liu, Wang, Liu, Li, Wang, Zhang, Sun, Xu (bib26) 2011; 10 Zhang (10.1016/j.ccr.2014.01.010_bib50) 2011; 30 Chan (10.1016/j.ccr.2014.01.010_bib5) 2011; 226 Guo (10.1016/j.ccr.2014.01.010_bib16) 2013; 23 Hamaratoglu (10.1016/j.ccr.2014.01.010_bib19) 2006; 8 Harvey (10.1016/j.ccr.2014.01.010_bib21) 2007; 7 Vaudin (10.1016/j.ccr.2014.01.010_bib44) 1999; 126 Jacobson (10.1016/j.ccr.2014.01.010_bib25) 2012; 5 Pobbati (10.1016/j.ccr.2014.01.010_bib38) 2012; 20 Jiang (10.1016/j.ccr.2014.01.010_bib26) 2011; 10 Chen (10.1016/j.ccr.2014.01.010_bib7) 2012; 3 Avruch (10.1016/j.ccr.2014.01.010_bib1) 2012; 11 Kang (10.1016/j.ccr.2014.01.010_bib28) 2011; 26 Zhou (10.1016/j.ccr.2014.01.010_bib56) 2013; 14 Cui (10.1016/j.ccr.2014.01.010_bib8) 2012; 25 Cai (10.1016/j.ccr.2014.01.010_bib4) 2010; 24 Zhang (10.1016/j.ccr.2014.01.010_bib57) 2014 Neto-Silva (10.1016/j.ccr.2014.01.010_bib36) 2010; 19 Zhao (10.1016/j.ccr.2014.01.010_bib54) 2011; 104 Halperin (10.1016/j.ccr.2014.01.010_bib18) 2013; 54 Wang (10.1016/j.ccr.2014.01.010_bib45) 2013; 51 Zeng (10.1016/j.ccr.2014.01.010_bib48) 2008; 13 Konsavage (10.1016/j.ccr.2014.01.010_bib29) 2012; 287 Zhao (10.1016/j.ccr.2014.01.010_bib51) 2007; 21 Fernandez (10.1016/j.ccr.2014.01.010_bib12) 2009; 23 Hergovich (10.1016/j.ccr.2014.01.010_bib22) 2012; 14 Han (10.1016/j.ccr.2014.01.010_bib20) 2002; 17 Wu (10.1016/j.ccr.2014.01.010_bib46) 2008; 14 Barry (10.1016/j.ccr.2014.01.010_bib3) 2013; 493 Lin (10.1016/j.ccr.2014.01.010_bib31) 2005; 11 Azzolin (10.1016/j.ccr.2014.01.010_bib2) 2012; 151 Koontz (10.1016/j.ccr.2014.01.010_bib30) 2013; 25 Varelas (10.1016/j.ccr.2014.01.010_bib43) 2010; 18 Houghton (10.1016/j.ccr.2014.01.010_bib23) 2005; 128 Faucheux (10.1016/j.ccr.2014.01.010_bib11) 2010; 54 Goulev (10.1016/j.ccr.2014.01.010_bib14) 2008; 18 Pan (10.1016/j.ccr.2014.01.010_bib37) 2010; 19 Sudol (10.1016/j.ccr.2014.01.010_bib41) 2012; 23 Da (10.1016/j.ccr.2014.01.010_bib9) 2009; 15 Genevet (10.1016/j.ccr.2014.01.010_bib13) 2010; 18 Danon (10.1016/j.ccr.2014.01.010_bib10) 1998; 3 Mann (10.1016/j.ccr.2014.01.010_bib35) 2012; 109 Takaishi (10.1016/j.ccr.2014.01.010_bib42) 2007; 98 Stanger (10.1016/j.ccr.2014.01.010_bib39) 2012; 26 Maeta (10.1016/j.ccr.2014.01.010_bib34) 2007; 73 Günther (10.1016/j.ccr.2014.01.010_bib15) 2004; 32 Zhang (10.1016/j.ccr.2014.01.010_bib49) 2008; 14 Liu-Chittenden (10.1016/j.ccr.2014.01.010_bib32) 2012; 26 Huang (10.1016/j.ccr.2014.01.010_bib24) 2005; 122 Jukam (10.1016/j.ccr.2014.01.010_bib27) 2013; 342 Maeda (10.1016/j.ccr.2014.01.010_bib33) 2002; 277 Chen (10.1016/j.ccr.2014.01.010_bib6) 2004; 279 Zhao (10.1016/j.ccr.2014.01.010_bib52) 2008; 22 Zhou (10.1016/j.ccr.2014.01.010_bib55) 2009; 16 Steinhardt (10.1016/j.ccr.2014.01.010_bib40) 2008; 39 Halder (10.1016/j.ccr.2014.01.010_bib17) 2011; 138 Zender (10.1016/j.ccr.2014.01.010_bib47) 2006; 125 Zhao (10.1016/j.ccr.2014.01.010_bib53) 2010; 24
References_xml	– volume: 3 start-page: 260 year: 1998 end-page: 268 ident: bib10 article-title: The role of gastric Helicobacter and N-methyl-N’-nitro- N-nitrosoguanidine in carcinogenesis of mice publication-title: Helicobacter – volume: 32 start-page: 791 year: 2004 end-page: 802 ident: bib15 article-title: VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation publication-title: Nucleic Acids Res. – volume: 22 start-page: 1962 year: 2008 end-page: 1971 ident: bib52 article-title: TEAD mediates YAP-dependent gene induction and growth control publication-title: Genes Dev. – volume: 54 start-page: 1375 year: 2010 end-page: 1382 ident: bib11 article-title: Vestigial like gene family expression in Xenopus: common and divergent features with other vertebrates publication-title: Int. J. Dev. Biol. – volume: 13 start-page: 188 year: 2008 end-page: 192 ident: bib48 article-title: The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals publication-title: Cancer Cell – volume: 10 start-page: 122 year: 2011 ident: bib26 article-title: Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination publication-title: Mol. Cancer – volume: 226 start-page: 928 year: 2011 end-page: 939 ident: bib5 article-title: The Hippo pathway in biological control and cancer development publication-title: J. Cell. Physiol. – volume: 21 start-page: 2747 year: 2007 end-page: 2761 ident: bib51 article-title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control publication-title: Genes Dev. – volume: 277 start-page: 48889 year: 2002 end-page: 48898 ident: bib33 article-title: Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation publication-title: J. Biol. Chem. – volume: 128 start-page: 1567 year: 2005 end-page: 1578 ident: bib23 article-title: Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers publication-title: Gastroenterology – volume: 14 start-page: 388 year: 2008 end-page: 398 ident: bib46 article-title: The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway publication-title: Dev. Cell – volume: 14 start-page: 377 year: 2008 end-page: 387 ident: bib49 article-title: The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control publication-title: Dev. Cell – volume: 138 start-page: 9 year: 2011 end-page: 22 ident: bib17 article-title: Hippo signaling: growth control and beyond publication-title: Development – volume: 109 start-page: 5934 year: 2012 end-page: 5941 ident: bib35 article-title: Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma publication-title: Proc. Natl. Acad. Sci. USA – volume: 104 start-page: 525 year: 2011 end-page: 529 ident: bib54 article-title: Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer publication-title: J. Surg. Oncol. – volume: 23 start-page: 1201 year: 2013 end-page: 1214 ident: bib16 article-title: A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity publication-title: Cell Res. – volume: 122 start-page: 421 year: 2005 end-page: 434 ident: bib24 article-title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP publication-title: Cell – volume: 26 start-page: 1300 year: 2012 end-page: 1305 ident: bib32 article-title: Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP publication-title: Genes Dev. – volume: 19 start-page: 507 year: 2010 end-page: 520 ident: bib36 article-title: Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap publication-title: Dev. Cell – volume: 25 start-page: 989 year: 2012 end-page: 1001 ident: bib8 article-title: YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl publication-title: Int. J. Immunopathol. Pharmacol. – year: 2014 ident: bib57 article-title: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex publication-title: Cell Res. – volume: 23 start-page: 2729 year: 2009 end-page: 2741 ident: bib12 article-title: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation publication-title: Genes Dev. – volume: 23 start-page: 827 year: 2012 end-page: 833 ident: bib41 article-title: Structures of YAP protein domains reveal promising targets for development of new cancer drugs publication-title: Semin. Cell Dev. Biol. – volume: 24 start-page: 2383 year: 2010 end-page: 2388 ident: bib4 article-title: The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program publication-title: Genes Dev. – volume: 7 start-page: 182 year: 2007 end-page: 191 ident: bib21 article-title: The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network publication-title: Nat. Rev. Cancer – volume: 14 start-page: 326 year: 2012 ident: bib22 article-title: YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer publication-title: Breast Cancer Res. – volume: 25 start-page: 388 year: 2013 end-page: 401 ident: bib30 article-title: The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression publication-title: Dev. Cell – volume: 98 start-page: 284 year: 2007 end-page: 293 ident: bib42 article-title: Gene expression profiling in a mouse model of Helicobacter-induced gastric cancer publication-title: Cancer Sci. – volume: 24 start-page: 862 year: 2010 end-page: 874 ident: bib53 article-title: The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version publication-title: Genes Dev. – volume: 279 start-page: 30800 year: 2004 end-page: 30806 ident: bib6 article-title: Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes publication-title: J. Biol. Chem. – volume: 126 start-page: 4807 year: 1999 end-page: 4816 ident: bib44 article-title: TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation publication-title: Development – volume: 39 start-page: 1582 year: 2008 end-page: 1589 ident: bib40 article-title: Expression of Yes-associated protein in common solid tumors publication-title: Hum. Pathol. – volume: 11 start-page: 1090 year: 2012 end-page: 1096 ident: bib1 article-title: YAP oncogene overexpression supercharges colon cancer proliferation publication-title: Cell Cycle – volume: 3 start-page: 305 year: 2012 end-page: 310 ident: bib7 article-title: Hippo pathway in intestinal homeostasis and tumorigenesis publication-title: Protein Cell – volume: 51 start-page: 211 year: 2013 end-page: 225 ident: bib45 article-title: TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function publication-title: Mol. Cell – volume: 30 start-page: 2810 year: 2011 end-page: 2822 ident: bib50 article-title: The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene publication-title: Oncogene – volume: 14 start-page: 5199 year: 2013 end-page: 5205 ident: bib56 article-title: Effects of the hippo signaling pathway in human gastric cancer publication-title: Asian Pac. J. Cancer Prev. – volume: 151 start-page: 1443 year: 2012 end-page: 1456 ident: bib2 article-title: Role of TAZ as mediator of Wnt signaling publication-title: Cell – volume: 18 start-page: 435 year: 2008 end-page: 441 ident: bib14 article-title: SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila publication-title: Curr. Biol. – volume: 8 start-page: 27 year: 2006 end-page: 36 ident: bib19 article-title: The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis publication-title: Nat. Cell Biol. – volume: 26 start-page: 1263 year: 2012 end-page: 1267 ident: bib39 article-title: Quit your YAPing: a new target for cancer therapy publication-title: Genes Dev. – volume: 287 start-page: 11730 year: 2012 end-page: 11739 ident: bib29 article-title: Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells publication-title: J. Biol. Chem. – volume: 20 start-page: 1135 year: 2012 end-page: 1140 ident: bib38 article-title: Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes publication-title: Structure – volume: 54 start-page: 473 year: 2013 end-page: 481 ident: bib18 article-title: Vestigial-like 3 is an inhibitor of adipocyte differentiation publication-title: J. Lipid Res. – volume: 18 start-page: 579 year: 2010 end-page: 591 ident: bib43 article-title: The Hippo pathway regulates Wnt/beta-catenin signaling publication-title: Dev. Cell – volume: 11 start-page: 5809 year: 2005 end-page: 5820 ident: bib31 article-title: Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway publication-title: Clin. Cancer Res – volume: 18 start-page: 300 year: 2010 end-page: 308 ident: bib13 article-title: Kibra is a regulator of the Salvador/Warts/Hippo signaling network publication-title: Dev. Cell – volume: 342 start-page: 1238016 year: 2013 ident: bib27 article-title: Opposite feedbacks in the Hippo pathway for growth control and neural fate publication-title: Science – volume: 15 start-page: 4055 year: 2009 end-page: 4061 ident: bib9 article-title: Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions publication-title: World J. Gastroenterol. – volume: 5 start-page: S8 year: 2012 ident: bib25 article-title: Connective tissue growth factor in tumor pathogenesis publication-title: Fibrogenesis Tissue Repair – volume: 125 start-page: 1253 year: 2006 end-page: 1267 ident: bib47 article-title: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach publication-title: Cell – volume: 73 start-page: 118 year: 2007 end-page: 126 ident: bib34 article-title: CYR61 downregulation correlates with tumor progression by promoting MMP-7 expression in human gastric carcinoma publication-title: Oncology – volume: 19 start-page: 491 year: 2010 end-page: 505 ident: bib37 article-title: The hippo signaling pathway in development and cancer publication-title: Dev. Cell – volume: 16 start-page: 425 year: 2009 end-page: 438 ident: bib55 article-title: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene publication-title: Cancer Cell – volume: 493 start-page: 106 year: 2013 end-page: 110 ident: bib3 article-title: Restriction of intestinal stem cell expansion and the regenerative response by YAP publication-title: Nature – volume: 26 start-page: 647 year: 2011 end-page: 653 ident: bib28 article-title: CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer publication-title: J. Korean Med. Sci. – volume: 17 start-page: 253 year: 2002 end-page: 261 ident: bib20 article-title: Helicobacter pylori infection promotes gastric carcinogenesis in a mice model publication-title: J. Gastroenterol. Hepatol. – volume: 19 start-page: 507 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib36 article-title: Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap publication-title: Dev. Cell doi: 10.1016/j.devcel.2010.09.009 – volume: 11 start-page: 1090 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib1 article-title: YAP oncogene overexpression supercharges colon cancer proliferation publication-title: Cell Cycle doi: 10.4161/cc.11.6.19453 – volume: 23 start-page: 1201 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib16 article-title: A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity publication-title: Cell Res. doi: 10.1038/cr.2013.120 – volume: 25 start-page: 388 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib30 article-title: The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression publication-title: Dev. Cell doi: 10.1016/j.devcel.2013.04.021 – volume: 73 start-page: 118 year: 2007 ident: 10.1016/j.ccr.2014.01.010_bib34 article-title: CYR61 downregulation correlates with tumor progression by promoting MMP-7 expression in human gastric carcinoma publication-title: Oncology doi: 10.1159/000121000 – volume: 20 start-page: 1135 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib38 article-title: Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes publication-title: Structure doi: 10.1016/j.str.2012.04.004 – volume: 18 start-page: 579 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib43 article-title: The Hippo pathway regulates Wnt/beta-catenin signaling publication-title: Dev. Cell doi: 10.1016/j.devcel.2010.03.007 – volume: 10 start-page: 122 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib26 article-title: Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination publication-title: Mol. Cancer doi: 10.1186/1476-4598-10-122 – volume: 54 start-page: 473 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib18 article-title: Vestigial-like 3 is an inhibitor of adipocyte differentiation publication-title: J. Lipid Res. doi: 10.1194/jlr.M032755 – volume: 125 start-page: 1253 year: 2006 ident: 10.1016/j.ccr.2014.01.010_bib47 article-title: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach publication-title: Cell doi: 10.1016/j.cell.2006.05.030 – volume: 18 start-page: 435 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib14 article-title: SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila publication-title: Curr. Biol. doi: 10.1016/j.cub.2008.02.034 – volume: 14 start-page: 377 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib49 article-title: The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.01.006 – volume: 22 start-page: 1962 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib52 article-title: TEAD mediates YAP-dependent gene induction and growth control publication-title: Genes Dev. doi: 10.1101/gad.1664408 – volume: 138 start-page: 9 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib17 article-title: Hippo signaling: growth control and beyond publication-title: Development doi: 10.1242/dev.045500 – volume: 109 start-page: 5934 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib35 article-title: Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1202490109 – volume: 98 start-page: 284 year: 2007 ident: 10.1016/j.ccr.2014.01.010_bib42 article-title: Gene expression profiling in a mouse model of Helicobacter-induced gastric cancer publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2007.00392.x – volume: 5 start-page: S8 issue: Suppl 1 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib25 article-title: Connective tissue growth factor in tumor pathogenesis publication-title: Fibrogenesis Tissue Repair doi: 10.1186/1755-1536-5-S1-S8 – volume: 51 start-page: 211 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib45 article-title: TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.05.013 – volume: 279 start-page: 30800 year: 2004 ident: 10.1016/j.ccr.2014.01.010_bib6 article-title: Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M400154200 – volume: 30 start-page: 2810 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib50 article-title: The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene publication-title: Oncogene doi: 10.1038/onc.2011.8 – volume: 16 start-page: 425 year: 2009 ident: 10.1016/j.ccr.2014.01.010_bib55 article-title: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.09.026 – volume: 7 start-page: 182 year: 2007 ident: 10.1016/j.ccr.2014.01.010_bib21 article-title: The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2070 – volume: 11 start-page: 5809 year: 2005 ident: 10.1016/j.ccr.2014.01.010_bib31 article-title: Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-04-2639 – volume: 25 start-page: 989 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib8 article-title: YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl publication-title: Int. J. Immunopathol. Pharmacol. doi: 10.1177/039463201202500416 – volume: 3 start-page: 305 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib7 article-title: Hippo pathway in intestinal homeostasis and tumorigenesis publication-title: Protein Cell doi: 10.1007/s13238-012-2913-9 – volume: 18 start-page: 300 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib13 article-title: Kibra is a regulator of the Salvador/Warts/Hippo signaling network publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.12.011 – year: 2014 ident: 10.1016/j.ccr.2014.01.010_bib57 article-title: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex publication-title: Cell Res. doi: 10.1038/cr.2014.10 – volume: 21 start-page: 2747 year: 2007 ident: 10.1016/j.ccr.2014.01.010_bib51 article-title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control publication-title: Genes Dev. doi: 10.1101/gad.1602907 – volume: 24 start-page: 2383 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib4 article-title: The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program publication-title: Genes Dev. doi: 10.1101/gad.1978810 – volume: 32 start-page: 791 year: 2004 ident: 10.1016/j.ccr.2014.01.010_bib15 article-title: VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkh248 – volume: 128 start-page: 1567 year: 2005 ident: 10.1016/j.ccr.2014.01.010_bib23 article-title: Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.03.037 – volume: 26 start-page: 1263 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib39 article-title: Quit your YAPing: a new target for cancer therapy publication-title: Genes Dev. doi: 10.1101/gad.196501.112 – volume: 277 start-page: 48889 year: 2002 ident: 10.1016/j.ccr.2014.01.010_bib33 article-title: Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M206858200 – volume: 54 start-page: 1375 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib11 article-title: Vestigial like gene family expression in Xenopus: common and divergent features with other vertebrates publication-title: Int. J. Dev. Biol. doi: 10.1387/ijdb.103080cf – volume: 17 start-page: 253 year: 2002 ident: 10.1016/j.ccr.2014.01.010_bib20 article-title: Helicobacter pylori infection promotes gastric carcinogenesis in a mice model publication-title: J. Gastroenterol. Hepatol. doi: 10.1046/j.1440-1746.2002.02684.x – volume: 23 start-page: 827 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib41 article-title: Structures of YAP protein domains reveal promising targets for development of new cancer drugs publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2012.05.002 – volume: 3 start-page: 260 year: 1998 ident: 10.1016/j.ccr.2014.01.010_bib10 article-title: The role of gastric Helicobacter and N-methyl-N’-nitro- N-nitrosoguanidine in carcinogenesis of mice publication-title: Helicobacter doi: 10.1046/j.1523-5378.1998.08017.x – volume: 122 start-page: 421 year: 2005 ident: 10.1016/j.ccr.2014.01.010_bib24 article-title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP publication-title: Cell doi: 10.1016/j.cell.2005.06.007 – volume: 24 start-page: 862 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib53 article-title: The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version publication-title: Genes Dev. doi: 10.1101/gad.1909210 – volume: 39 start-page: 1582 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib40 article-title: Expression of Yes-associated protein in common solid tumors publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2008.04.012 – volume: 23 start-page: 2729 year: 2009 ident: 10.1016/j.ccr.2014.01.010_bib12 article-title: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation publication-title: Genes Dev. doi: 10.1101/gad.1824509 – volume: 226 start-page: 928 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib5 article-title: The Hippo pathway in biological control and cancer development publication-title: J. Cell. Physiol. doi: 10.1002/jcp.22435 – volume: 151 start-page: 1443 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib2 article-title: Role of TAZ as mediator of Wnt signaling publication-title: Cell doi: 10.1016/j.cell.2012.11.027 – volume: 14 start-page: 388 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib46 article-title: The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.01.007 – volume: 493 start-page: 106 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib3 article-title: Restriction of intestinal stem cell expansion and the regenerative response by YAP publication-title: Nature doi: 10.1038/nature11693 – volume: 342 start-page: 1238016 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib27 article-title: Opposite feedbacks in the Hippo pathway for growth control and neural fate publication-title: Science doi: 10.1126/science.1238016 – volume: 14 start-page: 326 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib22 article-title: YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer publication-title: Breast Cancer Res. doi: 10.1186/bcr3349 – volume: 126 start-page: 4807 year: 1999 ident: 10.1016/j.ccr.2014.01.010_bib44 article-title: TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation publication-title: Development doi: 10.1242/dev.126.21.4807 – volume: 26 start-page: 647 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib28 article-title: CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer publication-title: J. Korean Med. Sci. doi: 10.3346/jkms.2011.26.5.647 – volume: 287 start-page: 11730 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib29 article-title: Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.327767 – volume: 19 start-page: 491 year: 2010 ident: 10.1016/j.ccr.2014.01.010_bib37 article-title: The hippo signaling pathway in development and cancer publication-title: Dev. Cell doi: 10.1016/j.devcel.2010.09.011 – volume: 14 start-page: 5199 year: 2013 ident: 10.1016/j.ccr.2014.01.010_bib56 article-title: Effects of the hippo signaling pathway in human gastric cancer publication-title: Asian Pac. J. Cancer Prev. doi: 10.7314/APJCP.2013.14.9.5199 – volume: 13 start-page: 188 year: 2008 ident: 10.1016/j.ccr.2014.01.010_bib48 article-title: The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.02.011 – volume: 26 start-page: 1300 year: 2012 ident: 10.1016/j.ccr.2014.01.010_bib32 article-title: Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP publication-title: Genes Dev. doi: 10.1101/gad.192856.112 – volume: 104 start-page: 525 year: 2011 ident: 10.1016/j.ccr.2014.01.010_bib54 article-title: Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer publication-title: J. Surg. Oncol. doi: 10.1002/jso.21984 – volume: 15 start-page: 4055 year: 2009 ident: 10.1016/j.ccr.2014.01.010_bib9 article-title: Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions publication-title: World J. Gastroenterol. doi: 10.3748/wjg.15.4055 – volume: 8 start-page: 27 year: 2006 ident: 10.1016/j.ccr.2014.01.010_bib19 article-title: The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis publication-title: Nat. Cell Biol. doi: 10.1038/ncb1339
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Snippet	The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However,...
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SubjectTerms	Animals Antimetabolites, Antineoplastic - pharmacology Case-Control Studies Cell Survival DNA-Binding Proteins - metabolism Female Fluorouracil - pharmacology Humans Immunoenzyme Techniques Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred ICR Middle Aged Molecular Mimicry Muscle Proteins - metabolism Neoplasm Invasiveness Neoplasm Staging Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Peptide Fragments - pharmacology Protein Conformation Stomach - metabolism Stomach - pathology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - prevention & control Tissue Array Analysis Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
Title	A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
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