Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

• Published in: Frontiers in microbiology Vol. 8; p. 900
• Main Authors: Gould, Victoria M W, Francis, James N, Anderson, Katie J, Georges, Bertrand, Cope, Alethea V, Tregoning, John S
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.05.2017
• Subjects: Human Infection Challenge study; IgA; influenza; Microbiology; nasal; vaccine; influenza; nasal; IgA; vaccine; Human Infection Challenge study

In spite of there being a number of vaccines, influenza remains a significant global cause of morbidity and mortality. Understanding more about natural and vaccine induced immune protection against influenza infection would help to develop better vaccines. Virus specific IgG is a known correlate of...