Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells

• Published in: Blood Vol. 88; no. 7; pp. 2442 - 2449
• Main Authors: Chakraborty, A, White, S M, Schaefer, T S, Ball, E D, Dyer, K F, Tweardy, D J
• Format: Journal Article
• Language: English
• Published: United States 01.10.1996
• Subjects: Acute Disease; Amino Acid Sequence; Base Sequence; Cell Differentiation - drug effects; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Leukemic - drug effects; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Humans; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - pathology; Molecular Sequence Data; Neoplasm Proteins - metabolism; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Signal Transduction - drug effects; STAT3 Transcription Factor; Trans-Activators - metabolism; Transcriptional Activation; Tumor Cells, Cultured

Granulocyte colony-stimulating factor (G-CSF) is the cytokine critical for directing neutrophilic granulocyte differentiation. Acute myelogenous leukemia (AML) cells, which frequently arise from this lineage, respond aberrantly to G-CSF by proliferating without differentiating. The basis for this ab...