Lipid Droplet-Related PLIN2 in CD68 + Tumor-Associated Macrophage of Oral Squamous Cell Carcinoma: Implications for Cancer Prognosis and Immunotherapy

• Published in: Frontiers in oncology Vol. 12; p. 824235
• Main Authors: He, Yijia, Dong, Yuexin, Zhang, Xinwen, Ding, Zhuang, Song, Yuxian, Huang, Xiaofeng, Chen, Sheng, Wang, Zhiyong, Ni, Yanhong, Ding, Liang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.03.2022
• Subjects: immune checkpoint; Oncology; oral squamous cell carcinoma; PLIN2; prognosis; tumor-associated macrophage; tumor-associated macrophage; PLIN2; oral squamous cell carcinoma; prognosis; immune checkpoint

PLIN2 (adipose differentiation-related protein) belongs to the perilipin family and is a marker of lipid droplets (LDs). Numerous types of tumor exhibit a high PLIN2 level, but its tumorigenic or tumor-suppressive role has been in debate. Recently, LDs serve as innate immune hubs and show antimicrob...