Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade

• Published in: Frontiers in immunology Vol. 11; p. 339
• Main Authors: Jiang, Youhai, Zhao, Xiaofang, Fu, Jing, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.03.2020
• Subjects: B7-H1 Antigen - analysis; Combined Modality Therapy; Gastrointestinal Microbiome; Humans; Immune Checkpoint Inhibitors - adverse effects; Immune Checkpoint Inhibitors - therapeutic use; Immunology; immunotherapy; Mutation; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - immunology; Obesity - complications; patient response; PD-1; PD-L1; precise treatment; Programmed Cell Death 1 Receptor - analysis; Tumor Microenvironment; PD-L1; precise treatment; patient response; PD-1; immunotherapy

Immune checkpoint inhibitors target the inhibitory receptors on T cells to reinstate their antitumor ability and have shown significant efficacy in treating various cancers. However, because of tumor heterogeneity and many other uncover reasons, the objective response rate for programmed death 1 and...