Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair

• Published in: Frontiers in cell and developmental biology Vol. 8; p. 263
• Main Authors: Sun, Ling, Zhu, Wenwu, Zhao, Pengcheng, Zhang, Jian, Lu, Yao, Zhu, Yeqian, Zhao, Wei, Liu, Yaowu, Chen, Qiushi, Zhang, Fengxiang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.05.2020
• Subjects: acute myocardial infarction; Cell and Developmental Biology; exosomes; mesenchymal stem cells; microRNA-221-3p; senescence; senescence; exosomes; mesenchymal stem cells; microRNA-221-3p; acute myocardial infarction

The composition and biological activity of donor cells is largely determined by the exosomes they secrete. In this study, we isolated exosomes from young (Young-Exo) and aged (Age-Exo) mesenchymal stem cells (MSCs) and compared their regeneration activity. Young Exo MSCs were more efficient than Age...