Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

• Published in: Frontiers in immunology Vol. 10; p. 1411
• Main Authors: Mak, Anselm, Dharmadhikari, Bhushan, Kow, Nien Yee, Thamboo, Thomas Paulraj, Tang, Qianqiao, Wong, Lik Wei, Sajikumar, Sreedharan, Wong, Hiu Yi, Schwarz, Herbert
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.06.2019
• Subjects: CD137 ligand; glomerulonephritis; Immunology; skin lesions; SLE; synaptic plasticity; Th17; CD137 ligand; skin lesions; synaptic plasticity; glomerulonephritis; SLE; Th17

The CD137-CD137 ligand (CD137L) costimulatory system is a critical immune checkpoint with pathophysiological implications in autoimmunity. In this study, we investigated the role of CD137L-mediated costimulation on renal, cutaneous and cerebral manifestations in lupus and the underlying immunologica...