Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction

• Published in: Frontiers in cardiovascular medicine Vol. 8; p. 647806
• Main Authors: Zhang, Beijian, Xu, Yamei, Cui, Xiaotong, Jiang, Hao, Luo, Wei, Weng, Xinyu, Wang, Yun, Zhao, Yuhong, Sun, Aijun, Ge, Junbo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.03.2021
• Subjects: Cardiovascular Medicine; epitranscriptomics; FTO; heart failure with preserved ejection fraction; METTL3; N6-methyladenosine; FTO; N6-methyladenosine; heart failure with preserved ejection fraction; epitranscriptomics; METTL3

Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined. Here, we explored the N 6 -methyladenosine (m6A) RNA methylation alteration in patients with HFpEF and mouse model of HFpEF. Methods: In this...