Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

• Published in: Frontiers in immunology Vol. 10; p. 885
• Main Authors: Savelli, Stephanie L., Roubey, Robert A. S., Kitzmiller, Kathryn J., Zhou, Danlei, Nagaraja, Haikady N., Mulvihill, Evan, Barbar-Smiley, Fatima, Ardoin, Stacy P., Wu, Yee Ling, Yu, Chack-Yung
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.05.2019
• Subjects: C3 and C4; C4A and C4B; Copy number variation; Factor H; Immunology; Lupus anticoagulant; Mannan binding lectin; Factor H; Copy number variation; C3 and C4; C4A and C4B; Recurrent pregnancy loss; Mannan binding lectin; Thrombosis; Lupus anticoagulant

APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10-15% have a manifestation of secondary APS. Animal studies suggested that complement activation plays an important role in the pathogen...