Impact of trial design and patient heterogeneity on the identification of clinically effective therapies for progressive MS

• Published in: Multiple sclerosis Vol. 24; no. 14; p. 1795
• Main Authors: Mills, Elizabeth A, Begay, Joel A, Fisher, Caitlyn, Mao-Draayer, Yang
• Format: Journal Article
• Language: English
• Published: England 01.12.2018
• Subjects: Progressive multiple sclerosis; clinical trial; neurodegeneration; immunomodulatory therapy

Clinically effective immunomodulatory therapies have been developed for relapsing-remitting multiple sclerosis (RRMS), but they have generally not translated to a corresponding slowing of disability accumulation in progressive forms of multiple sclerosis (MS). Since disability is multifaceted, progr...