P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus

• Published in: Frontiers in pharmacology Vol. 10; p. 435
• Main Authors: Furini, Federica, Giuliani, Anna Lisa, Parlati, Mattia Erminio, Govoni, Marcello, Di Virgilio, Francesco, Bortoluzzi, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.04.2019
• Subjects: IL-1β; IL-6; NLRP3 inflammasome; P2X7R; Pharmacology; serositis; Systemic Lupus Erythematosus; Systemic Lupus Erythematosus; serositis; IL-1β; NLRP3 inflammasome; IL-6; P2X7R

P2X7R is an extracellular ATP-gated receptor involved in inflammatory and autoimmune processes mainly acting through NLPR3-inflammasome activation and IL-1β release, also implicated in lymphocyte proliferation and cellular apoptosis. Several observations from animal models and patients' studies...