Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms

• Published in: Frontiers in oncology Vol. 10; p. 584367
• Main Authors: Chen, Jianyu, Zhang, Honghao, Zhou, Lijuan, Hu, Yuxing, Li, Meifang, He, Yanjie, Li, Yuhua
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.02.2021
• Subjects: combination therapies; immune evasion; immunotherapy; Oncology; tumor microenvironment; tumor vaccines; tumor microenvironment; immune evasion; tumor vaccines; combination therapies; immunotherapy

Tumor vaccines aim to expand tumor-specific T cells and reactivate existing tumor-specific T cells that are in a dormant or unresponsive state. As such, there is growing interest in improving the durable anti-tumor activity of tumor vaccines. Failure of vaccine-activated T cells to protect against t...