Extended two-stage adaptive designs with three target responses for phase II clinical trials

• Published in: Statistical methods in medical research Vol. 27; no. 12; p. 3628
• Main Authors: Kim, Seongho, Wong, Weng Kee
• Format: Journal Article
• Language: English
• Published: England 01.12.2018
• Subjects: Adaptive Clinical Trials as Topic; Algorithms; Clinical Trials, Phase II as Topic; Humans; Melanoma - drug therapy; Models, Statistical; Research Design; Sample Size; sequential design; Adaptive design; Simon’s two-stage design; particle swarm optimization; power; greedy algorithm

We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization to find extended two-stage adaptive optimal designs that allow three target response rates for the drug in a phase II trial. Our proposed designs include the celebrated Simon's tw...