Clinical and pathologic factors associated with subclinical spread of invasive melanoma

• Published in: Journal of the American Academy of Dermatology Vol. 76; no. 4; pp. 714 - 721
• Main Authors: Shin, Thuzar M., Shaikh, Waqas R., Etzkorn, Jeremy R., Sobanko, Joseph F., Margolis, David J., Gelfand, Joel M., Chu, Emily Y., Elenitsas, Rosalie, Miller, Christopher J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017
• Subjects: Adult; Age Factors; Aged; appropriate use criteria; Cross-Sectional Studies; Dermatology; excision; Female; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - surgery; Humans; Hutchinson's Melanotic Freckle - immunology; Hutchinson's Melanotic Freckle - pathology; Hutchinson's Melanotic Freckle - surgery; Immunocompetence; invasive melanoma; Male; MART-1 Antigen - analysis; MART-1 Antigen - immunology; Melanoma - immunology; Melanoma - pathology; Melanoma - surgery; Melanoma, Cutaneous Malignant; Middle Aged; Mitotic Index; Mohs micrographic surgery; Mohs Surgery; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - prevention & control; Neoplasm, Residual; Plastic Surgery Procedures; Retrospective Studies; Risk Factors; Skin Neoplasms - immunology; Skin Neoplasms - pathology; Skin Neoplasms - surgery; subclinical spread; T-Lymphocytes - immunology; excision; OR; NCCN; subclinical spread; MART-1; CI; ROC; SLNB; appropriate use criteria; Mohs micrographic surgery; WLE; MMS; invasive melanoma; AJCC; sentinel lymph node biopsy; wide local excision; odds ratio; American Joint Committee on Cancer; confidence interval; National Comprehensive Cancer Network; melanoma antigen recognized by T cells 1; receiver operating characteristic

Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined. Identify clinical and histologic factors associated with subclinical spread of invasive melanoma. This retrospective, cross-section...