Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice

• Published in: Frontiers in pharmacology Vol. 8; p. 782
• Main Authors: Brito, Victor, Mellal, Katia, Zoccal, Karina F, Soto, Yosdel, Ménard, Liliane, Sarduy, Roger, Faccioli, Lucia H, Ong, Huy, Vázquez, Ana M, Marleau, Sylvie
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.11.2017
• Subjects: active immunization; atherosclerosis; glycosaminoglycans; interleukin-6; Pharmacology; proteoglycans; regression; atherosclerosis; glycosaminoglycans; proteoglycans; active immunization; regression; interleukin-10; interleukin-6; vascular cell adhesion molecule-1

The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation. Administration of chP3R99, a chimeric mouse/human monoclonal antibody inducing an anti-idiotypic network response against glycosami...