Mechanobiological Feedback in Pulmonary Vascular Disease

• Published in: Frontiers in physiology Vol. 9; p. 951
• Main Authors: Dieffenbach, Paul B, Maracle, Marcy, Tschumperlin, Daniel J, Fredenburgh, Laura E
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.07.2018
• Subjects: cellular mechanosensors; mechanotransduction; Physiology; pulmonary arterial stiffness; pulmonary hypertension; vascular stiffness; YAP/TAZ; pulmonary arterial stiffness; YAP/TAZ; cellular mechanosensors; mechanotransduction; pulmonary hypertension; matrix stiffness; vascular stiffness; vascular remodeling

Vascular stiffening in the pulmonary arterial bed is increasingly recognized as an early disease marker and contributor to right ventricular workload in pulmonary hypertension. Changes in pulmonary artery stiffness throughout the pulmonary vascular tree lead to physiologic alterations in pressure an...