Are bacterial vaccine antigens T-cell epitope depleted?
For many infectious diseases, protective immunity can be elicited by vaccination with pathogen-derived proteins. Peptides derived from these proteins are bound to major histocompatibility complex (MHC) molecules and presented to T-cell receptors to stimulate an immune response. We show here that, pa...
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| Published in | Immunology today (Amsterdam. Regular ed.) Vol. 29; no. 8; pp. 374 - 379 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2008
Elsevier Limited |
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| Abstract | For many infectious diseases, protective immunity can be elicited by vaccination with pathogen-derived proteins. Peptides derived from these proteins are bound to major histocompatibility complex (MHC) molecules and presented to T-cell receptors to stimulate an immune response. We show here that, paradoxically, bacterial proteins known experimentally to elicit a protective immune response are relatively depleted in peptides predicted to bind to human MHC alleles. We propose three nonconflicting reasons for this: the lack of precision of current predictive software, the low incidence of hydrophobic residues in vaccine antigens or evolutionary pressure exerted on bacteria by the immune system. We suggest that there is little value in predicting candidate vaccines based on high MHC-binding epitope density. |
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| AbstractList | For many infectious diseases, protective immunity can be elicited by vaccination with pathogen-derived proteins. Peptides derived from these proteins are bound to major histocompatibility complex (MHC) molecules and presented to T-cell receptors to stimulate an immune response. We show here that, paradoxically, bacterial proteins known experimentally to elicit a protective immune response are relatively depleted in peptides predicted to bind to human MHC alleles. We propose three nonconflicting reasons for this: the lack of precision of current predictive software, the low incidence of hydrophobic residues in vaccine antigens or evolutionary pressure exerted on bacteria by the immune system. We suggest that there is little value in predicting candidate vaccines based on high MHC-binding epitope density. |
| Author | Titball, Richard W Moss, David S Sansom, Clare E Halling-Brown, Mark Davies, Matthew |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18603471$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Algorithms Allergy and Immunology Antigen Presentation - immunology Antigens, Bacterial - immunology Bacteria Bacterial proteins Bacterial Vaccines - immunology Epitope Mapping - methods Epitopes, T-Lymphocyte - immunology Humans Immune system Major Histocompatibility Complex - immunology Peptides Software T cell receptors Vaccines |
| Title | Are bacterial vaccine antigens T-cell epitope depleted? |
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