Senescence Inducer Shikonin ROS-Dependently Suppressed Lung Cancer Progression

• Published in: Frontiers in pharmacology Vol. 9; p. 519
• Main Authors: Zheng, Hongming, Huang, Qiuju, Huang, Suchao, Yang, Xia, Zhu, Ting, Wang, Wensheng, Wang, Haojia, He, Shugui, Ji, Liyan, Wang, Ying, Qi, Xiaoxiao, Liu, Zhongqiu, Lu, Linlin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.05.2018
• Subjects: DNA damage; lung cancer; Pharmacology; ROS; senescence; shikonin; lung cancer; senescence; DNA damage; ROS; shikonin

Lung adenocarcinoma (LAC), predominant subclassfication of lung cancer, leads high incidence and mortality annually worldwide. During the premalignant transition from lung adenomas to LAC, cellular senescence is regard as a critical physiological barrier against tumor progression. Nevertheless, the...