The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans - Varnäs, Katarina; Cselényi, Zsolt; Arakawa, Ryosuke; Nag, Sangram; Stepanov, Vladimir; Moein, Mohammad Mahdi; Johnström, Peter; Kingston, Lee; Elmore, Charles S.; Halldin, Christer; Farde, Lars (Neuropharmacology, 2020)
Keywords: Adult; Allosteric Regulation; Animals; Autoradiography; AZD9272; Binding Sites; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes; Female; Fenobam; Humans; Imidazoles - adverse effects; Imidazoles - metabolism; Macaca fascicularis; Male; Metabotropic glutamate receptor 5; Middle Aged; Monoamine Oxidase - metabolism; Monoamine Oxidase Inhibitors - metabolism; Monoamine oxidase-B; Oxadiazoles - adverse effects; Oxadiazoles - metabolism; Oximes - metabolism; PET imaging; Positron-Emission Tomography; Psychoses, Substance-Induced - etiology; Pyridines - adverse effects; Pyridines - metabolism; Radiopharmaceuticals - metabolism; Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors; Selegiline - metabolism; Young Adult; DVR; MRIs; ID50; MA; IC50; NHP; AIC; BPND; Fenobam; ROIs; PET imaging; PSL; MAO-B; HRRT; Autoradiography; Monoamine oxidase-B; HEPES; FWHM; NAM; Metabotropic glutamate receptor 5; AZD9272; mGluR5; Ki; PET; VT