Adaptive Memory of Human NK-like CD8 + T-Cells to Aging, and Viral and Tumor Antigens

• Published in: Frontiers in immunology Vol. 7; p. 616
• Main Authors: Pita-López, María Luisa, Pera, Alejandra, Solana, Rafael
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.12.2016
• Subjects: Aging; CMV; Immunology; immunosenescence; Memory; Natural killer receptors; T-cell differentiation; immunosenescence; memory; natural killer receptors; T-cell differentiation; NK-like CD8+ T-cells; aging; CD56; CMV

Human natural killer (NK)-like CD8 T-cells are singular T-cells that express both T and NK cell markers such as CD56; their frequencies depend on their differentiation and activation during their lifetime. There is evidence of the presence of these innate CD8 T-cells in the human umbilical cord, hig...