Application of FLP-FRT System to Construct Unmarked Deletion in Helicobacter pylori and Functional Study of Gene hp0788 in Pathogenesis

• Published in: Frontiers in microbiology Vol. 8; p. 2357
• Main Authors: Ji, Xiaofei, Wang, Ying, Li, Jiaojiao, Rong, Qianyu, Chen, Xingxing, Zhang, Ying, Liu, Xiaoning, Li, Boqing, Zhao, Huilin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.11.2017
• Subjects: cell apoptosis; FLP-FRT; Helicobacter pylori; hp0788; Microbiology; unmarked deletion; cell apoptosis; unmarked deletion; FLP-FRT; Helicobacter pylori; hp0788

is a Gram-negative, microaerophilic bacterium associated with human gastric diseases. Further investigations on virulence genes are still required to clarify the pathogenic mechanism of and the heterogeneous problem of infection. In order to develop an efficient and accurate method to study gene fun...