Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi019-A) from a patient with Charcot-Marie-Tooth disease type 2A2 (CMT2A2) due to a heterozygous missense substitution c.2119C > T (p.Arg707Trp) in MFN2 gene

Charcot-Marie-Tooth disease (CMT) is an inherited neurological disorder characterized by the progressive damage of the peripheral nerves. We generated a human induced pluripotent stem cell (iPSC) line JUCTCi019-A using dermal fibroblasts-derived from a 50-year-old CMT2A2 patient carrying a heterozyg...

Full description

Saved in:
Bibliographic Details
Published inStem cell research Vol. 62; p. 102786
Main Authors Ababneh, Nidaa A., Barham, Raghda, Al-Kurdi, Ban, Ali, Dema, Hadidi, Sabal Al, A. Ismail, Mohammad, Muamar, Ahmed S.H., Abdulelah, Ahmed A., Madadha, Adan, Sallam, Malik, Hassona, Yazan, Masri, Amira, Awidi, Abdalla
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.07.2022
Elsevier
Online AccessGet full text

Cover

Abstract Charcot-Marie-Tooth disease (CMT) is an inherited neurological disorder characterized by the progressive damage of the peripheral nerves. We generated a human induced pluripotent stem cell (iPSC) line JUCTCi019-A using dermal fibroblasts-derived from a 50-year-old CMT2A2 patient carrying a heterozygous missense substitution c.2119C > T (p.Arg707Trp) in the MFN2 gene. Fibroblasts were reprogrammed by Sendai viruses encoding for the reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. Characterization showed normal iPSC morphology and karyotype, expression of pluripotency markers and differentiation into three-germ layers. This iPSC line represents an ideal source for disease modelling and drug development of CMT2A2 disease.
AbstractList Charcot-Marie-Tooth disease (CMT) is an inherited neurological disorder characterized by the progressive damage of the peripheral nerves. We generated a human induced pluripotent stem cell (iPSC) line JUCTCi019-A using dermal fibroblasts-derived from a 50-year-old CMT2A2 patient carrying a heterozygous missense substitution c.2119C > T (p.Arg707Trp) in the MFN2 gene. Fibroblasts were reprogrammed by Sendai viruses encoding for the reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. Characterization showed normal iPSC morphology and karyotype, expression of pluripotency markers and differentiation into three-germ layers. This iPSC line represents an ideal source for disease modelling and drug development of CMT2A2 disease.
ArticleNumber 102786
Author Hassona, Yazan
Ali, Dema
Al-Kurdi, Ban
Sallam, Malik
Awidi, Abdalla
Hadidi, Sabal Al
Ababneh, Nidaa A.
A. Ismail, Mohammad
Abdulelah, Ahmed A.
Muamar, Ahmed S.H.
Madadha, Adan
Barham, Raghda
Masri, Amira
Author_xml – sequence: 1
  givenname: Nidaa A.
  surname: Ababneh
  fullname: Ababneh, Nidaa A.
  email: n.ababneh@ju.edu.jo
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 2
  givenname: Raghda
  surname: Barham
  fullname: Barham, Raghda
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 3
  givenname: Ban
  surname: Al-Kurdi
  fullname: Al-Kurdi, Ban
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 4
  givenname: Dema
  surname: Ali
  fullname: Ali, Dema
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 5
  givenname: Sabal Al
  surname: Hadidi
  fullname: Hadidi, Sabal Al
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 6
  givenname: Mohammad
  surname: A. Ismail
  fullname: A. Ismail, Mohammad
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 7
  givenname: Ahmed S.H.
  surname: Muamar
  fullname: Muamar, Ahmed S.H.
  organization: Department of Otolaryngology, School of Medicine, The University of Jordan, Amman, Jordan
– sequence: 8
  givenname: Ahmed A.
  surname: Abdulelah
  fullname: Abdulelah, Ahmed A.
  organization: School of Medicine, The University of Jordan, Amman, Jordan
– sequence: 9
  givenname: Adan
  surname: Madadha
  fullname: Madadha, Adan
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
– sequence: 10
  givenname: Malik
  surname: Sallam
  fullname: Sallam, Malik
  organization: Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan
– sequence: 11
  givenname: Yazan
  surname: Hassona
  fullname: Hassona, Yazan
  organization: Department of Oral and Maxillofacial Surgery, Oral Medicine, and Periodontics, School of Dentistry, The University of Jordan, Amman, Jordan
– sequence: 12
  givenname: Amira
  surname: Masri
  fullname: Masri, Amira
  organization: Department of Paediatrics, Division of Child Neurology, School of Medicine, The University of Jordan, Jordan
– sequence: 13
  givenname: Abdalla
  surname: Awidi
  fullname: Awidi, Abdalla
  organization: Cell Therapy Center, The University of Jordan, Amman, Jordan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35468369$$D View this record in MEDLINE/PubMed
BookMark eNp9Ustu1DAUjVARfcAHsEFeziwy2E6ch5CQRhEtRR1AIl1bjnMz9SgTp7YDGr6m39Jv4UO4M1O6ZGX76pxz7z0-59HJYAeIoreMLhhl2fvNwmu34JRzfPO8yF5EZ6zIszjPRXJyuCexoBk7jc6931AqSl7wV9FpItKsSLLyLPpzBQM4FYwdiO2IInfTVg3EDO2koSVjPzkz2gBDID7AlmjoezIz339Uc9KbAcjsy21VV4ayMl7OSefsFkVGFNxTfplwR6o75bQN8Uo5A3FtLdZa40F5IGE3AuFLTmbVqsZzTtoJq3Y_CARw9vdubSdPtsZ7GJDgp8YHE6bDwHrBGSurx4ePjw81mY2LpVvnNK_dOMcNyOryKydr3O919LJTvYc3T-dFdHv5qa4-xzffrq6r5U2s04yHmCmRsVSLptMFawVrylxRzZpU6FY1nDORC1XQpEwZK9q07DRtUq07KlSrBXTJRXR91G2t2sjRma1yO2mVkYeCdWupXDC6B6m7giVpmdEUW6q8LNqGKZyCJ0yzJE9Ra3bUGp29n8AHiR7s3VcDoCOSZ0IIpPMSoewI1c5676B7bs2o3AdFbiQGRe6DIo9BQc67J_mp2UL7zPiXDAR8OAIADftpwKEE_imGwjjQATcy_5H_CyF1zlY
CitedBy_id crossref_primary_10_3389_fncel_2023_1248922
crossref_primary_10_3389_fnmol_2022_974480
Cites_doi 10.1016/j.scr.2020.101923
10.1016/j.cca.2021.10.001
10.1016/j.scr.2020.101925
10.1186/1471-2350-11-48
ContentType Journal Article
Copyright 2022 The Authors
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2022 The Authors
– notice: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
DBID 6I.
AAFTH
NPM
AAYXX
CITATION
7X8
DOA
DOI 10.1016/j.scr.2022.102786
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
PubMed
CrossRef
MEDLINE - Academic
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1876-7753
EndPage 102786
ExternalDocumentID oai_doaj_org_article_cf81349604614a798db1a462231c1374
10_1016_j_scr_2022_102786
35468369
S1873506122001350
Genre Journal Article
GroupedDBID ---
--K
.~1
0R~
0SF
123
1B1
1~.
1~5
4.4
457
4G.
53G
5VS
6I.
7-5
71M
AACTN
AAEDT
AAEDW
AAFTH
AAIKJ
AALRI
AAQFI
AAXUO
ABBQC
ABCQJ
ABGSF
ABMAC
ACGFS
ADBBV
ADEZE
ADMUD
ADUVX
AEKER
AENEX
AEXQZ
AFTJW
AGHFR
AGWIK
AGYEJ
AITUG
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
BCNDV
CS3
DU5
EBS
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FNPLU
GBLVA
GROUPED_DOAJ
HVGLF
HZ~
IHE
IPNFZ
IXB
J1W
KQ8
M41
M48
MO0
N9A
NCXOZ
O-L
O9-
OK1
OZT
P-8
P-9
P2P
PC.
Q38
RIG
ROL
RPZ
SDF
SDG
SES
SSZ
ADVLN
AFJKZ
AKRWK
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c462t-1a5614c5bfc81d51b97a0c1b45cdab221575a80394118d49fc0b4ccf05adc5ef3
IEDL.DBID M48
ISSN 1873-5061
IngestDate Tue Oct 22 15:13:57 EDT 2024
Fri Oct 25 08:01:49 EDT 2024
Thu Sep 26 17:34:41 EDT 2024
Sat Sep 28 08:17:58 EDT 2024
Fri Feb 23 02:36:33 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License This is an open access article under the CC BY license.
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c462t-1a5614c5bfc81d51b97a0c1b45cdab221575a80394118d49fc0b4ccf05adc5ef3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.scr.2022.102786
PMID 35468369
PQID 2655560429
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_cf81349604614a798db1a462231c1374
proquest_miscellaneous_2655560429
crossref_primary_10_1016_j_scr_2022_102786
pubmed_primary_35468369
elsevier_sciencedirect_doi_10_1016_j_scr_2022_102786
PublicationCentury 2000
PublicationDate 2022-07-01
PublicationDateYYYYMMDD 2022-07-01
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Stem cell research
PublicationTitleAlternate Stem Cell Res
PublicationYear 2022
Publisher Elsevier B.V
Elsevier
Publisher_xml – name: Elsevier B.V
– name: Elsevier
References Ababneh, Ali, Al-Kurdi, Barham, Bsisu, Dababseh, Arafat, Khanfar, Makahleh, Ryalat, Sallam, El-Khateeb, Sharrack, Awidi (b0020) 2021; 523
Ababneh, Al-Kurdi, Ali, Abuarqoub, Barham, Salah, Awidi (b0010) 2020; 47
Ababneh, Al-Kurdi, Ali, Abuarqoub, Barham, Alzibdeh, Awidi (b0005) 2020; 48
Braathen, Sand, Lobato, Høyer, Russell (b0025) 2010; 11
Ababneh, Al-Kurdi, Ali, Barham, Sharar, Mrahleh, Awidi (b0015) 2020; 48
Ababneh (10.1016/j.scr.2022.102786_b0015) 2020; 48
Braathen (10.1016/j.scr.2022.102786_b0025) 2010; 11
Ababneh (10.1016/j.scr.2022.102786_b0005) 2020; 48
Ababneh (10.1016/j.scr.2022.102786_b0010) 2020; 47
Ababneh (10.1016/j.scr.2022.102786_b0020) 2021; 523
References_xml – volume: 11
  year: 2010
  ident: b0025
  article-title: MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families
  publication-title: BMC Med. Genet.
  contributor:
    fullname: Russell
– volume: 523
  start-page: 330
  year: 2021
  end-page: 338
  ident: b0020
  article-title: The utility of whole-exome sequencing in accurate diagnosis of neuromuscular disorders in consanguineous families in Jordan
  publication-title: Clin. Chim. Acta
  contributor:
    fullname: Awidi
– volume: 48
  year: 2020
  ident: b0015
  article-title: Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi011-A) from skin fibroblasts of a healthy Jordanian male subject
  publication-title: Stem Cell Res.
  contributor:
    fullname: Awidi
– volume: 47
  year: 2020
  ident: b0010
  article-title: Establishment of a human induced pluripotent stem cell (iPSC) line (JUCTCi010-A) from a healthy Jordanian female skin dermal fibroblasts
  publication-title: Stem Cell Res.
  contributor:
    fullname: Awidi
– volume: 48
  year: 2020
  ident: b0005
  article-title: Generation and characterization of induced pluripotent stem cell (iPSC) line (JUCTCi002-A) from a patient with ataxia with oculomotor apraxia type 1 (AOA1) harboring a homozygous mutation in the APTX gene
  publication-title: Stem Cell Res.
  contributor:
    fullname: Awidi
– volume: 48
  year: 2020
  ident: 10.1016/j.scr.2022.102786_b0015
  article-title: Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi011-A) from skin fibroblasts of a healthy Jordanian male subject
  publication-title: Stem Cell Res.
  doi: 10.1016/j.scr.2020.101923
  contributor:
    fullname: Ababneh
– volume: 47
  issue: June
  year: 2020
  ident: 10.1016/j.scr.2022.102786_b0010
  article-title: Establishment of a human induced pluripotent stem cell (iPSC) line (JUCTCi010-A) from a healthy Jordanian female skin dermal fibroblasts
  publication-title: Stem Cell Res.
  contributor:
    fullname: Ababneh
– volume: 523
  start-page: 330
  year: 2021
  ident: 10.1016/j.scr.2022.102786_b0020
  article-title: The utility of whole-exome sequencing in accurate diagnosis of neuromuscular disorders in consanguineous families in Jordan
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2021.10.001
  contributor:
    fullname: Ababneh
– volume: 48
  year: 2020
  ident: 10.1016/j.scr.2022.102786_b0005
  article-title: Generation and characterization of induced pluripotent stem cell (iPSC) line (JUCTCi002-A) from a patient with ataxia with oculomotor apraxia type 1 (AOA1) harboring a homozygous mutation in the APTX gene
  publication-title: Stem Cell Res.
  doi: 10.1016/j.scr.2020.101925
  contributor:
    fullname: Ababneh
– volume: 11
  issue: 1
  year: 2010
  ident: 10.1016/j.scr.2022.102786_b0025
  article-title: MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families
  publication-title: BMC Med. Genet.
  doi: 10.1186/1471-2350-11-48
  contributor:
    fullname: Braathen
SSID ssj0059282
Score 2.3516226
Snippet Charcot-Marie-Tooth disease (CMT) is an inherited neurological disorder characterized by the progressive damage of the peripheral nerves. We generated a human...
SourceID doaj
proquest
crossref
pubmed
elsevier
SourceType Open Website
Aggregation Database
Index Database
Publisher
StartPage 102786
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NatwwEBYlUOil9L_bNmEKPewWlPpH8s8lsDVdQmBDoV7ITUiyHDa09rLxHtKnybPkWfogmbHskB7aXnpaY2zvWDOe-UYafcPYh0TUOqzimtsk01wY6dAP4hE6zCoVGUJ2RxuFl6fJ8UqcnMmze62-qCbM0wP7gftk64wY9BIiBhc6zbPKhFokGNVCG8apZwIN8jGZ8j5Y5lHfJirM0phLDFnjemZf2YXfIyaGUUS0BSltor4XkXri_t8C05-AZx-AFk_Y4wE5wtxL_JQ9cM0z9tD3krx6zn55AmkaZ2hr0NB33wNMuVF5FWy-79A9tIiQOyDuZqAZe5iuv34rZkBQE6Ynq6Is1gjG-HwGtO0EHzLQrgJN1wItzdu240vKr3nZopJhWOABmsqFaB7BtFiW-DuDaodnWxKEKm7an1fn7e4SftD6f4M3XKLH6ssUSGB7SBRwxc310c11CdPN4Xx7ngZpud3M8A1guTiNAC3dvWCrxZeyOOZDCwduUUcdDzUxjVppaovAWIYmT3VgQyOkrbSJEG-kUmdBnAtMdCqR1zYwwto6kLqy0tXxS7bXtI17zQCBoiQyG2Fo3iqWWksdZg4vkwT88gn7OKpRbTxThxpL2C4U6lyRzpXX-YR9JkXfXUgk2_0JND01mJ76l-lNmBjNRA14xeMQfNT6b__9fjQphYNO6taNQxWoKJESEShChAl75W3tTsJYiiSLk_zN_5D8LXtEAvmy43dsr9vu3D6Cq84c9N_RLQBAGvg
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ScienceDirect Open Access Journals (Elsevier)
  dbid: IXB
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NattAEF5CINBL6X_dnzCFHuyCYkm7q59LwBE1IeBQiAy-LauVZFRaSTjyIX2aPEuepQ_SmZUUkkN76Mn2spZWO6OZb3ZnvmXscyBK7eW8dEwQaUdkskA7iN_QYOahiBCyF1QovLoMztfiYiM3BywZa2EorXKw_b1Nt9Z6aJkPszlvq2p-5UUhl-ShKS2I27ido3emIr7N2WiNZezbA6Oos0O9x51Nm-OFbyaGiL5PBAYhlVM_8E2Wwv-Ri_obBLWuaPmMPR0wJCz6YT5nB0X9gh31p0revGS_eyppmnFoStBgz-EDDL5RjDm0P_ZoKBrEyh0QizPQ2j1Mq29XyQwIdML0Yp2kSYWwzFnMgApQ8CIDASvQwi3QJr1pOmdFkbaTNihuGLZ6gBZ1wV_4ME1WKX7OIN9ja0MDodyb5tfNttlfw0_KBKjxD9dou2zCAg3YnBAZXHJ3e3p3m8K0PVnstqEbprt2hk8Aq-WlD6jzxSu2Xn5Nk3NnOMzBMSLwO8fTxDlqZFYahMjSy-JQu8bLhDS5znxEHqHUkctjgSFPLuLSuJkwpnSlzo0sSv6aHdZNXbxlgJBREq2NyGgFi0utpfaiArtJgoDxhH0ZxajanrNDjcls3xXKXJHMVS_zCTsjQd93JLpt29DstmrQN2XKiGgcA2KnFzqMozzzND4WgmPj8VBMmBjVRD3SXrxU9a97fxpVSuGkk7h1XaAIlB9IiVgUwcKEvel17X6EXIog4kH87v9u-p49oV99yvEHdtjt9sVHBFZddmzfnD8xXByY
  priority: 102
  providerName: Elsevier
Title Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi019-A) from a patient with Charcot-Marie-Tooth disease type 2A2 (CMT2A2) due to a heterozygous missense substitution c.2119C > T (p.Arg707Trp) in MFN2 gene
URI https://dx.doi.org/10.1016/j.scr.2022.102786
https://www.ncbi.nlm.nih.gov/pubmed/35468369
https://search.proquest.com/docview/2655560429
https://doaj.org/article/cf81349604614a798db1a462231c1374
Volume 62
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9NAFB52VwRfxLv1Uo7gQyukNJOZZPKg0g2WdaWLYgp9C5NJUiprUtMUrA_-lv0t-1v8IZ6TS2Vh9cmXNIRkejLfXL45c_Idxl66ItN24mSWcZW2RCxTHAfxDAfMxBMKKXtKHwrPztyTuThdyMUB69JbtRW4uXZpR_mk5uX56Pu33Vvs8K__xGphD8OlHuckROAp95Dd4KTLRZF8Yr-pIH1e546yledYEuexbpPzuiKuTFO1mv-V2epvbLSelaZ32O2WTsKkwf8uO0jze-xmk2Byd5_9alSlqfKhyEBDnZIPcB2OiCawPt_imFEgba6ABJ2B3PgwWH38HAyB-CcMTudBGKyQoVmTIdC3KFhIq8UK5MMF2q83RWXNaNFthQUiD-2uD5B_F_iEwyCYhfg7hGSLVwsyhMJwih-7ZbHdwFcKCsjxgQ0OY3XsAhlsRqQLF1xevLm8CGGwHk3KpTf2wnI9xDeA2fSMAzb_9AGbT9-FwYnV5nWwjHB5Zdma5EeNjDODbFnase_psbFjIU2iY44kxJNajR1f4OonEX5mxrEwJhtLnRiZZs5DdpQXefqYAbJHSQo3IiZnliO1ltpWKd4miQ36PfaqgzFaN_IdURfX9iVCzCPCPGow77FjAnp_Iylv1xeKchm1HTkymSJFR5eE6oX2fJXEtsbXQp5sbMcTPSa6ZhK1JKYhJ1jU6l___aJrUhFWOsGt8xQhiLgrJdJS5A099qhpa3sLHSlc5bj-k_9h-VN2iwxqYpGfsaOq3KbPkXFVcZ8djn7a_dpfgcf3i2M8fvik-nX_-g1Ksifj
link.rule.ids 315,783,787,867,2109,3515,4511,24332,27938,27939,45599,45888
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIgSXivJcoDBIHHaR0s3DzuOCtI1YbUuzQmpW2pvlOMkqqCTRNnsov6a_pb-FH8JMHhU9wIFTIsdJHM9k_I0985mxjy7PlZU6uaFdXxk8ERnaQTxDg5l63EfInlGicLR0Fyt-thbrPRYOuTAUVtnb_s6mt9a6L5n2vTmti2J6YfmeI2iEprAgh_z2B5R2SXFdp-uTwRyLwG53jKLaBlUfljbbIC_8NdFHtG1iMPAon_qPwanl8L83Rv0Ng7Zj0fwJO-hBJMy6dh6yvax8yh5220peP2O_Oi5p6nKoclDQbsQH6H2jHFOoL3doKSoEyw0QjTPQ5D2Mi28X4QQIdcL4bBXGYYG4zJhNgDJQ8CE9AyvQzC3QKr2uGiMiV9uIK5Q39Gs9QLO6YM9sGIdRjMcJpDssraghFHxT_bzeVLsr-EGhACXecIXGq41YoAbrY2KDC29vPt_exDCuj2fbjWd68bae4BdANF_agEqfPWer-Zc4XBj9bg6G5q7dGJYi0lEtklwjRhZWEnjK1FbChU5VYiP08ITyTSfg6POkPMi1mXCtc1OoVIssd16w_bIqs1cMEDMK4rXhCU1hOUIpoSw_w2qCMGAwYp8GMcq6I-2QQzTbd4kylyRz2cl8xE5I0HcViW-7Lai2G9krnNS5TzyOLtHTc-UFfppYCj8L0bG2HI-PGB_URN5TX3xU8a93fxhUSmKnk7hVmaEIpO0KgWAU0cKIvex07a6FjuCu77jB6_976Xv2aBFH5_L8dPn1DXtMV7r447dsv9nusiNEWU3yrv2LfgOtsx_G
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Generation+of+a+human+induced+pluripotent+stem+cell+%28iPSC%29+line+%28JUCTCi019-A%29+from+a+patient+with+Charcot-Marie-Tooth+disease+type+2A2+%28CMT2A2%29+due+to+a+heterozygous+missense+substitution+c.2119C%C2%A0%3E%C2%A0T+%28p.Arg707Trp%29+in+MFN2+gene&rft.jtitle=Stem+cell+research&rft.au=Nidaa+A.+Ababneh&rft.au=Raghda+Barham&rft.au=Ban+Al-Kurdi&rft.au=Dema+Ali&rft.date=2022-07-01&rft.pub=Elsevier&rft.issn=1873-5061&rft.volume=62&rft.spage=102786&rft_id=info:doi/10.1016%2Fj.scr.2022.102786&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_cf81349604614a798db1a462231c1374
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1873-5061&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1873-5061&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1873-5061&client=summon