Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro

• Published in: Carbohydrate polymers Vol. 84; no. 1; pp. 118 - 125
• Main Authors: Zhang, Ling, Li, Kuifeng, Xiao, Wenqian, Zheng, Li, Xiao, Yumei, Fan, Hongsong, Zhang, Xingdong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 11.02.2011; Elsevier
• Subjects: Applied sciences; biocompatibility; Biological and medical sciences; Biomimetic; biomimetics; cartilage; Cartilage tissue engineering; chondrocytes; Collagen; crosslinking; Exact sciences and technology; extracellular matrix; gelatinization temperature; Glycosaminoglycans; hydrocolloids; Hydrogel; in vitro studies; Medical sciences; Natural polymers; Physicochemistry of polymers; Proteins; Starch and polysaccharides; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; tissue engineering; tissue scaffolds; Cartilage tissue engineering; Glycosaminoglycans; Hydrogel; Biomimetic; Collagen; Biological properties; Cell proliferation; Chondrocyte; Biodegradability; Aglycone; Property processing relationship; Colloidal gel; Water absorption; Biomaterial; Framework; Tissue engineering; Mechanical properties; Crosslinking; Experimental study; In vitro; Protein; Structure processing relationship; Morphology; Preparation; Oside polymer; Chondroitin sulfate; Kinetics; Hyaluronic acid

Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible. The aim of this study was to develop a biomimetic hydrogel scaffold with good operability and stability by collagen self-assembly. To improve physical and chemical performances, the hydrogels...