Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro
Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible. The aim of this study was to develop a biomimetic hydrogel scaffold with good operability and stability by collagen self-assembly. To improve physical and chemical performances, the hydrogels...
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| Published in | Carbohydrate polymers Vol. 84; no. 1; pp. 118 - 125 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
11.02.2011
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible. The aim of this study was to develop a biomimetic hydrogel scaffold with good operability and stability by collagen self-assembly. To improve physical and chemical performances, the hydrogels were crosslinked with different concentrations of genipin using gel-crosslinking method. Morphology, crosslinking index, and content of glycosaminoglycans of the hydrogel scaffolds were characterized. The potential of the hydrogels as cartilage tissue engineering scaffolds was evaluated by compression test, swelling measurement, in vitro degradation assay, and biocompatibility study in vitro. Results showed that hydrogel scaffold crosslinked with 0.75mM genipin exhibited balanced optimal properties, and excellent cellular compatibility. Since gelation was temperature sensitive and crosslink occurred under mild conditions, the hydrogel scaffold may be well suited as a carrier for chondrocytes transplantation or as cartilage tissue engineering scaffolds. |
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| AbstractList | Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible. The aim of this study was to develop a biomimetic hydrogel scaffold with good operability and stability by collagen self-assembly. To improve physical and chemical performances, the hydrogels were crosslinked with different concentrations of genipin using gel-crosslinking method. Morphology, crosslinking index, and content of glycosaminoglycans of the hydrogel scaffolds were characterized. The potential of the hydrogels as cartilage tissue engineering scaffolds was evaluated by compression test, swelling measurement, in vitro degradation assay, and biocompatibility study in vitro. Results showed that hydrogel scaffold crosslinked with 0.75mM genipin exhibited balanced optimal properties, and excellent cellular compatibility. Since gelation was temperature sensitive and crosslink occurred under mild conditions, the hydrogel scaffold may be well suited as a carrier for chondrocytes transplantation or as cartilage tissue engineering scaffolds. |
| Author | Zhang, Xingdong Zheng, Li Xiao, Yumei Xiao, Wenqian Fan, Hongsong Li, Kuifeng Zhang, Ling |
| Author_xml | – sequence: 1 givenname: Ling surname: Zhang fullname: Zhang, Ling – sequence: 2 givenname: Kuifeng surname: Li fullname: Li, Kuifeng – sequence: 3 givenname: Wenqian surname: Xiao fullname: Xiao, Wenqian – sequence: 4 givenname: Li surname: Zheng fullname: Zheng, Li – sequence: 5 givenname: Yumei surname: Xiao fullname: Xiao, Yumei – sequence: 6 givenname: Hongsong surname: Fan fullname: Fan, Hongsong email: hsfan@scu.edu.cn – sequence: 7 givenname: Xingdong surname: Zhang fullname: Zhang, Xingdong |
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| Keywords | Cartilage tissue engineering Glycosaminoglycans Hydrogel Biomimetic Collagen Biological properties Cell proliferation Chondrocyte Biodegradability Aglycone Property processing relationship Colloidal gel Water absorption Biomaterial Framework Tissue engineering Mechanical properties Crosslinking Experimental study In vitro Protein Structure processing relationship Morphology Preparation Oside polymer Chondroitin sulfate Kinetics Hyaluronic acid |
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| SubjectTerms | Applied sciences biocompatibility Biological and medical sciences Biomimetic biomimetics cartilage Cartilage tissue engineering chondrocytes Collagen crosslinking Exact sciences and technology extracellular matrix gelatinization temperature Glycosaminoglycans hydrocolloids Hydrogel in vitro studies Medical sciences Natural polymers Physicochemistry of polymers Proteins Starch and polysaccharides Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments tissue engineering tissue scaffolds |
| Title | Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro |
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