Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema

• Published in: Frontiers in immunology Vol. 7; p. 553
• Main Authors: Qiu, Shi-Lin, Duan, Min-Chao, Liang, Yi, Tang, Hai-Juan, Liu, Guang-Nan, Zhang, Liang-Ming, Yang, Chao-Mian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.12.2016
• Subjects: Cigarette smoke exposure; COPD; IL-27/WSX-1; Immunology; smoking mouse model of emphysema; Th1 Cells; Th17 Cells; cigarette smoke exposure; IL-27/WSX-1; Th1 cells; COPD; Th17 cells
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2016.00553

IFN-γ-producing CD4 T (Th1) cells and IL-17-producing CD4 T (Th17) cells play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune regulation between Th1 and Th17 cells remains unclear. Previous studies have demonstrated that interleukin-27 (IL-27)...