Alcohol induces mitochondrial redox imbalance in alveolar macrophages - Liang, Yan; Harris, Frank L.; Jones, Dean P.; Brown, Lou Ann S. (Free radical biology & medicine, 2013)
Keywords: alcohol abuse; Alcohol Drinking; Animals; antioxidant activity; Cell Line; Central Nervous System Depressants - administration & dosage; Central Nervous System Depressants - pharmacology; ethanol; Ethanol - administration & dosage; Ethanol - pharmacology; Glutaredoxins - biosynthesis; glutathione; Glutathione - metabolism; Glutathione Peroxidase; Glutathione Reductase - biosynthesis; glutathione-disulfide reductase; immune response; macrophages; Macrophages, Alveolar - immunology; messenger RNA; Mice; Mice, Inbred C57BL; mitochondria; Mitochondria - pathology; NADP (coenzyme); NADP - metabolism; oxidants; oxidation; Oxidation-Reduction - drug effects; Oxidative Stress; Peroxiredoxins - metabolism; phagocytosis; Phagocytosis - drug effects; Phagocytosis - immunology; proteins; reactive oxygen species; Reactive Oxygen Species - metabolism; risk; RNA, Messenger - biosynthesis; Signal Transduction - immunology; thiols; Thioredoxin-Disulfide Reductase - genetics; Thioredoxin-Disulfide Reductase - metabolism; Thioredoxins - metabolism; peroxiredoxin; Grx; Thioredoxin; glutaredoxin; Gpx; nicotinamide nucleotide transhydrogenase; relative fluorescence units; Prdx; nicotinamide adenine dinucleotide; Mitochondria; NNT; Alveolar macrophage; reactive oxygen species; glutathione (reduced); NADP; glutathione reductase; thioredoxin reductase 2; GSH; RFU; GSSG; Peroxiredoxin hyperoxidation; Free radicals; nicotinamide adenine dinucleotide phosphate; GR; AM; TrxR2; NAD; thioredoxin 2; glutathione (oxidized); ROS; Chronic alcohol ingestion; Trx2; glutathione peroxidase