Lens aging: Effects of crystallins

• Published in: Biochimica et biophysica acta Vol. 1790; no. 10; pp. 1095 - 1108
• Main Authors: Sharma, K. Krishna, Santhoshkumar, Puttur
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2009
• Subjects: Aging; Aging - metabolism; Animals; Cataract - metabolism; Cataract - pathology; Chaperone; Crystallins - metabolism; Deamidation; Glycation; Glycosylation; Humans; Lens crystallin; Lens opacity; Lens, Crystalline - metabolism; Models, Biological; Oxidation; Oxidation-Reduction; Peptide; Phosphorylation; Lens crystallin; Chaperone; Aging; Lens opacity; Deamidation; Oxidation; Peptide; Glycation

The primary function of the eye lens is to focus light on the retina. The major proteins in the lens—α, β, and γ-crystallins—are constantly subjected to age-related changes such as oxidation, deamidation, truncation, glycation, and methylation. Such age-related modifications are cumulative and affec...