Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 172; pp. 30 - 44
• Main Authors: Sakamuri, Siva S.V.P., Takawale, Abhijit, Basu, Ratnadeep, Fedak, Paul W.M., Freed, Darren, Sergi, Consolato, Oudit, Gavin Y., Kassiri, Zamaneh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: ADAMTS Proteins - metabolism; Adult; Basement Membrane - metabolism; Biomechanical Phenomena; Collagen - metabolism; Extracellular Matrix - chemistry; Extracellular Matrix - metabolism; Female; Fibrosis; Heart Failure - physiopathology; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Heart-Assist Devices; Humans; Integrin beta1 - metabolism; Internal Medicine; Male; Models, Biological; Myocardium - metabolism; Osteonectin - metabolism; Osteopontin - metabolism; Proteolysis; RNA, Messenger - genetics; RNA, Messenger - metabolism; Solubility; Tissue Inhibitor of Metalloproteinases - genetics; Tissue Inhibitor of Metalloproteinases - metabolism; BiVAD; OCT; SPARC; LV; IQR; EDTA; OPN; ECM; LVAD; PSR; DCM; MMP; ADAMTS2; MT1-MMP; RT-PCR; ACEi; TGFβ; HF; biventricular assist device; left ventricle; transforming growth factor beta; secreted protein acidic and rich in cysteine; angiotensin-converting-enzyme inhibitor; interquartile range; picrosirius red; ethylenediaminetetraacetic acid; dilated cardiomyopathy; heart failure; osteopontin; A disintegrin and metalloproteinase with thrombospondin motifs 2; membrane type 1-matrix metalloproteinase; optimal cutting temperature; reverse transcription polymerase chain reaction; matrix metalloproteinase; left ventricular assist device; extracellular matrix

Adverse remodeling of the extracellular matrix (ECM) is a significant characteristic of heart failure. Reverse remodeling of the fibrillar ECM secondary to mechanical unloading of the left ventricle (LV) by left ventricular assist device (LVAD) has been subject of intense investigation; however, lit...