c-MYC inhibition impairs hypoxia response in glioblastoma multiforme - Mongiardi, Maria Patrizia; Savino, Mauro; Falchetti, Maria Laura; Illi, Barbara; Bozzo, Francesca; Valle, Cristiana; Helmer-Citterich, Manuela; Ferrè, Fabrizio; Nasi, Sergio; Levi, Andrea (Oncotarget, 2016)
Keywords: Antineoplastic Agents - pharmacology; Binding Sites; Brain Neoplasms - drug therapy; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Energy Metabolism - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Glioblastoma - drug therapy; Glioblastoma - genetics; Glioblastoma - metabolism; Glioblastoma - pathology; Glycolysis - drug effects; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Peptide Fragments - pharmacology; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc - antagonists & inhibitors; Proto-Oncogene Proteins c-myc - metabolism; Proto-Oncogene Proteins c-myc - pharmacology; Research Paper; Signal Transduction - drug effects; Time Factors; Transcription, Genetic - drug effects; Tumor Hypoxia; Tumor Microenvironment; hypoxia; glioblastoma; HIF; c-MYC; glycolysis