Coral-Derived Endophytic Fungal Product, Butyrolactone-I, Alleviates Lps Induced Intestinal Epithelial Cell Inflammatory Response Through TLR4/NF-κB and MAPK Signaling Pathways: An in vitro and in vivo Studies

• Published in: Frontiers in nutrition (Lausanne) Vol. 8; p. 748118
• Main Authors: Chen, Shengwei, Zhang, Yi, Niu, Xueting, Mohyuddin, Sahar Ghulam, Wen, Jiayin, Bao, Minglong, Yu, Tianyue, Wu, Lianyun, Hu, Canyin, Yong, Yanhong, Liu, Xiaoxi, Abd El-Aty, A M, Ju, Xianghong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.10.2021
• Subjects: anti-inflammatory; butyrolactone-I; IBD; intestinal barrier; MAPK; Nutrition; TLR4/NF-κB; anti-inflammatory; IBD; butyrolactone-I; MAPK; intestinal barrier; TLR4/NF-κB

Herein, we assessed the anti-inflammatory and intestinal barrier protective effects of butyrolactone-I (BTL-1), derived from the coral-derived endophytic fungus ( ), using the LPS-induced IPEC-J2 inflammation model and the DSS-induced IBD model in mice. In IPEC-J2 cells, pretreatment with BTL-I sign...