The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho‐physiological background

• Published in: The FASEB journal Vol. 37; no. 11; pp. e23209 - n/a
• Main Authors: Irshad, Zehra, Lund, Jenny, Sillars, Anne, Løvsletten, Nils Gunnar, Gharanei, Seley, Salt, Ian P., Freeman, Dilys J., Gill, Jason M. R., Thoresen, G. Hege, Rustan, Arild C., Zammit, Victor A.
• Format: Journal Article
• Language: English
• Published: United States 01.11.2023
• Subjects: Acetates; diacylglycerol acyltransferases; Diacylglycerol O-Acyltransferase - genetics; Diacylglycerol O-Acyltransferase - metabolism; fatty acid oxidation; Fatty Acids - metabolism; Glucose - metabolism; Humans; Insulin; insulin resistance; lipogenesis; Male; Muscle Fibers, Skeletal - metabolism; muscle lipid; triacylglycerols; Triglycerides - metabolism; lipogenesis; triacylglycerols; fatty acid oxidation; insulin resistance; diacylglycerol acyltransferases; muscle lipid

The roles of DGAT1 and DGAT2 in lipid metabolism and insulin responsiveness of human skeletal muscle were studied using cryosections and myotubes prepared from muscle biopsies from control, athlete, and impaired glucose regulation (IGR) cohorts of men. The previously observed increases in intramuscu...