Renal Net Acid Excretion Capacity Is Comparable in Prepubescence, Adolescence, and Young Adulthood but Falls with Aging
OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. DESIGN: Cross‐sectional observational study. SETTING: Community‐based. PARTICIPANTS: Young participants were from the DOrtmund Nutritiona...
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| Published in | Journal of the American Geriatrics Society (JAGS) Vol. 56; no. 8; pp. 1442 - 1448 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.08.2008
Blackwell Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-8614 1532-5415 1532-5415 |
| DOI | 10.1111/j.1532-5415.2008.01799.x |
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| Abstract | OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people.
DESIGN: Cross‐sectional observational study.
SETTING: Community‐based.
PARTICIPANTS: Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden.
MEASUREMENTS: Twenty‐four‐hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55–75; n=85), young adults (aged 18–22; n=117), adolescents (aged 13–14; n=112), and prepubescent children (aged 6–7; n=217). NAEC was determined as 24‐hour NAE adjusted for urine pH using the residual method.
RESULTS: In elderly participants 24‐hour urinary pH (5.9±0.53) was lower (P<.05) and NAE (60±27 mEq/d) higher (P<.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants (P<.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults.
CONCLUSION: The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. |
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| AbstractList | To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people.OBJECTIVESTo evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people.Cross-sectional observational study.DESIGNCross-sectional observational study.Community-based.SETTINGCommunity-based.Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden.PARTICIPANTSYoung participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden.Twenty-four-hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55-75; n=85), young adults (aged 18-22; n=117), adolescents (aged 13-14; n=112), and prepubescent children (aged 6-7; n=217). NAEC was determined as 24-hour NAE adjusted for urine pH using the residual method.MEASUREMENTSTwenty-four-hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55-75; n=85), young adults (aged 18-22; n=117), adolescents (aged 13-14; n=112), and prepubescent children (aged 6-7; n=217). NAEC was determined as 24-hour NAE adjusted for urine pH using the residual method.In elderly participants 24-hour urinary pH (5.9+/-0.53) was lower (P<.05) and NAE (60+/-27 mEq/d) higher (P<.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants (P<.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults.RESULTSIn elderly participants 24-hour urinary pH (5.9+/-0.53) was lower (P<.05) and NAE (60+/-27 mEq/d) higher (P<.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants (P<.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults.The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses.CONCLUSIONThe capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. DESIGN: Cross‐sectional observational study. SETTING: Community‐based. PARTICIPANTS: Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden. MEASUREMENTS: Twenty‐four‐hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55–75; n=85), young adults (aged 18–22; n=117), adolescents (aged 13–14; n=112), and prepubescent children (aged 6–7; n=217). NAEC was determined as 24‐hour NAE adjusted for urine pH using the residual method. RESULTS: In elderly participants 24‐hour urinary pH (5.9±0.53) was lower ( P <.05) and NAE (60±27 mEq/d) higher ( P <.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants ( P <.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults. CONCLUSION: The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. DESIGN: Cross‐sectional observational study. SETTING: Community‐based. PARTICIPANTS: Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden. MEASUREMENTS: Twenty‐four‐hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55–75; n=85), young adults (aged 18–22; n=117), adolescents (aged 13–14; n=112), and prepubescent children (aged 6–7; n=217). NAEC was determined as 24‐hour NAE adjusted for urine pH using the residual method. RESULTS: In elderly participants 24‐hour urinary pH (5.9±0.53) was lower (P<.05) and NAE (60±27 mEq/d) higher (P<.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants (P<.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults. CONCLUSION: The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. Cross-sectional observational study. Community-based. Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden. Twenty-four-hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55-75; n=85), young adults (aged 18-22; n=117), adolescents (aged 13-14; n=112), and prepubescent children (aged 6-7; n=217). NAEC was determined as 24-hour NAE adjusted for urine pH using the residual method. In elderly participants 24-hour urinary pH (5.9+/-0.53) was lower (P<.05) and NAE (60+/-27 mEq/d) higher (P<.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants (P<.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults. The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. Cross-sectional observational study. Community-based. Young participants were from the Dortmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, Germany; elderly participants were from Gothenburg, Sweden. Twenty-four-hour urine pH, net acid excretion (NAE), urinary phosphorus, total nitrogen excretion, and anthropometric data were measured in healthy elderly people (aged 55-75; n=85), young adults (aged 18-22; n=117), adolescents (aged 13-14; n=112), and prepubescent children (aged 6-7; n=217). NAEC was determined as 24-hour NAE adjusted for urine pH using the residual method. In elderly participants 24-hour urinary pH (5.9±0.53) was lower ( P <.05) and NAE (60±27 mEq/d) higher ( P <.05) than in the three other groups. In a regression model adjusted for age, sex, and body surface area, NAEC showed a clear decrease with age, with highest values in prepubescents and lowest in elderly participants. However, NAEC remained significantly lower only in elderly participants ( P <.001) after the inclusion of total nitrogen excretion, a protein intake index, which was included because protein intake is known to modulate renal function. NAEC was approximately 8 mEq/d lower in healthy elderly participants than in young adults. The capacity to excrete net endogenous acid does not vary markedly from childhood to young adulthood but falls significantly with age, implying that elderly people may require higher daily alkalizing mineral intake to compensate for renal function losses. [PUBLICATION ABSTRACT] |
| Author | Rylander, Ragnar Vormann, Jürgen Günther, Anke L. B. Berkemeyer, Shoma Remer, Thomas Frassetto, Lynda A. |
| Author_xml | – sequence: 1 givenname: Shoma surname: Berkemeyer fullname: Berkemeyer, Shoma organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California – sequence: 2 givenname: Jürgen surname: Vormann fullname: Vormann, Jürgen organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California – sequence: 3 givenname: Anke L. B. surname: Günther fullname: Günther, Anke L. B. organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California – sequence: 4 givenname: Ragnar surname: Rylander fullname: Rylander, Ragnar organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California – sequence: 5 givenname: Lynda A. surname: Frassetto fullname: Frassetto, Lynda A. organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California – sequence: 6 givenname: Thomas surname: Remer fullname: Remer, Thomas organization: From theResearch Institute of Child Nutrition, Dortmund, Germany†Institute for Prevention and Nutrition, Ismaning, Germany‡BioFact Environmental Health Research Center, Lerum, Sweden§Department of Medicine, University of California at San Francisco, San Francisco, California |
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| Keywords | Human Kidney disease Excretion Senescence Urinary system disease Renal function Healthy subject healthy subjects Ageing net acid excretion capacity Base Protein Kidney Urinary system Acids Capacity Adolescent Young adult Fall Pharmacokinetics acid-base Elderly Geriatrics |
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Manz F, Wentz A. Renal net acid excretion related to body surface area in children and adolescents. DONALD (DOrtmund Nutritional and Anthropometric Longitudinally Designed) Study. Pediatr Nephrol 2000;15:101-104. Remer T, Berkemeyer S, Rylander R et al. Muscularity and adiposity in addition to net acid excretion as predictors of 24-h urinary pH in young adults and elderly. Eur J Clin Nutr 2007;61:605-609. Schurch MA, Rizzoli R, Slosman D et al. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998;128:801-809. Remer T, Neubert A, Maser-Gluth C. Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research. Am J Clin Nutr 2002;75:561-569. Bingham SA. Urine nitrogen as a biomarker for the validation of dietary protein intake. 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| References_xml | – reference: Alexy U, Remer T, Manz F et al. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr 2005;82:1107-1114. – reference: Manz F, Wentz A. Renal net acid excretion related to body surface area in children and adolescents. DONALD (DOrtmund Nutritional and Anthropometric Longitudinally Designed) Study. Pediatr Nephrol 2000;15:101-104. – reference: Rowe JW, Andres R, Tobin JD et al. The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study. J Gerontol 1976;31:155-163. – reference: Poortmans JR, Ouchinsky M. Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men. J Gerontol A Biol Sci Med Sci 2006;61:1181-1185. – reference: Manz F, Remer T, Decher-Spliethoff E et al. Effects of a high protein intake on renal acid excretion in bodybuilders. Z Ernahrungswiss 1995;34:10-15. – reference: Molnar D, Schutz Y. Fat oxidation in nonobese and obese adolescents: Effect of body composition and pubertal development. J Pediatr 1998;132:98-104. – reference: Rylander R, Remer T, Berkemeyer S et al. Acid-base status affects renal magnesium losses in healthy, elderly persons. J Nutr 2006;136:2374-2377. – reference: O'Donnell MP, Kasiske BL, Raij L et al. Age is a determinant of the glomerular morphologic and functional responses to chronic nephron loss. J Lab Clin Med 1985;106:308-313. – reference: Laing CM, Unwin RJ. Renal tubular acidosis. J Nephrol 2006;19 (Suppl 9):S46-S52. – reference: Lüthy C, Moser C, Oetliker O. Three-phasic acid/base titration in urine. Med Lab 1977;30:174-181. – reference: Frassetto LA, Morris RC Jr, Sebastian A. Effect of age on blood acid-base composition in adult humans: Role of age-related renal functional decline. Am J Physiol 1996;271:F1114-F1122. – reference: Remer T, Neubert A, Maser-Gluth C. Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research. Am J Clin Nutr 2002;75:561-569. – reference: Remer T, Manz F. Dietary protein as a modulator of the renal net acid excretion capacity: Evidence that an increased protein intake improves the capability of the kidney to excrete ammonium. Nutr Biochem 1995;6:431-437. – reference: Jehle S, Zanetti A, Muser J et al. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia. J Am Soc Nephrol 2006;17:3213-3222. – reference: Buemi M, Nostro L, Aloisi C et al. Kidney aging: From phenotype to genetics. Rejuvenat Res 2005;8:101-109. – reference: Schurch MA, Rizzoli R, Slosman D et al. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998;128:801-809. – reference: Frassetto LA, Todd KM, Morris RC Jr et al. Worldwide incidence of hip fracture in elderly women: Relation to consumption of animal and vegetable foods. J Gerontol A Biol Sci Med Sci 2000;55:M585-M592. – reference: Tasevska N, Runswick SA, Bingham SA. Urinary potassium is as reliable as urinary nitrogen for use as a recovery biomarker in dietary studies of free living individuals. J Nutr 2006;136:1334-1340. – reference: Hirschberg R, Rottka H, Von Herrath D et al. Effect of an acute protein load on the creatinine clearance in healthy vegetarians. Klin Wochenschr 1985;63:217-220. – reference: Fliser D, Ritz E, Franek E. Renal reserve in the elderly. Semin Nephrol 1995;15:463-467. – reference: Watkin DM, Schock NW. Age-wise standard value for CIN, CPAH, and TmPAH in adult males. J Clin Invest 1955;34:969. – reference: Remer T, Fonteyn N, Alexy U et al. Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status. Am J Clin Nutr 2006;83:639-646. – reference: Goodman AD, Lemann J Jr, Lennon EJ et al. Production, excretion, and net balance of fixed acid in patients with renal acidosis. J Clin Invest 1965;44:495-506. – reference: Kildeberg P. Disturbances of hydrogen ion balance occurring in premature infants. II. Late metabolic acidosis. Acta Paediatr 1964;53:517-526. – reference: Remer T, Manz F. Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 1995;95:791-797. – reference: Hayton WL. Maturation and growth of renal function: Dosing renally cleared drugs in children. AAPS PharmSci 2000;2:E3. – reference: Adler S, Lindeman RD, Yiengst MJ et al. Effect of acute acid loading on urinary acid excretion by the aging human kidney. J Lab Clin Med 1968;72:278-289. – reference: Bingham SA. Urine nitrogen as a biomarker for the validation of dietary protein intake. J Nutr 2003;133 (Suppl 3):921S-924S. – reference: Manz F, Wentz A, Lange S. Factors affecting renal hydrogen ion excretion capacity in healthy children. Pediatr Nephrol 2001;16:443-445. – reference: Rubin MI, Bruck E, Rapoport M et al. Maturation of renal function in childhood: Clearance Studies. J Clin Invest 1949;28:1144-1162. – reference: Kalhoff H, Manz F, Diekmann L et al. Decreased growth rate of low-birth-weight infants with prolonged maximum renal acid stimulation. Acta Paediatr 1993;82:522-527. – reference: Berkemeyer S, Remer T. Anthropometrics provide a better estimate of urinary organic acid anion excretion than a dietary mineral intake-based estimate in children, adolescents, and young adults. J Nutr 2006;136:1203-1208. – reference: Remer T, Berkemeyer S, Rylander R et al. Muscularity and adiposity in addition to net acid excretion as predictors of 24-h urinary pH in young adults and elderly. Eur J Clin Nutr 2007;61:605-609. – reference: Sebastian A. Dietary protein content and the diet's net acid load: Opposing effects on bone health. Am J Clin Nutr 2005;82:921-922. – reference: Gonick HC, Kleeman CR, Rubini ME et al. Functional impairment in chronic renal disease. II. Studies of acid excretion. Nephron 1969;6:28-49. – reference: Wang Y, Moss J, Thisted R. Predictors of body surface area. J Clin Anesth 1992;4:4-10. – reference: Hostetter TH. Human renal response to meat meal. Am J Physiol 1986;250:F613-F618. – reference: Manz F, Kalhoff H, Remer T. Renal acid excretion in early infancy. Pediatr Nephrol 1997;11:231-243. – reference: Bartels H, Cikes M. Chromogens in the creatinine determination of Jaffe [Ueber Chromegene der Keatininbestimmung nach Jaffe]. 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Late metabolic acidosis publication-title: Acta Paediatr – volume: 75 start-page: 561 year: 2002 end-page: 569 article-title: Anthropometry‐based reference values for 24‐h urinary creatinine excretion during growth and their use in endocrine and nutritional research publication-title: Am J Clin Nutr – volume: 271 start-page: F1114 year: 1996 end-page: F1122 article-title: Effect of age on blood acid‐base composition in adult humans publication-title: Role of age-related renal functional decline – volume: 106 start-page: 308 year: 1985 end-page: 313 article-title: Age is a determinant of the glomerular morphologic and functional responses to chronic nephron loss publication-title: J Lab Clin Med – volume: 133 start-page: 921S issue: (Suppl 3) year: 2003 end-page: 924S article-title: Urine nitrogen as a biomarker for the validation of dietary protein intake publication-title: J Nutr – volume: 15 start-page: 101 year: 2000 end-page: 104 article-title: Renal net acid excretion related to body surface area in children and adolescents. 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A randomized, double‐blind, placebo‐controlled trial publication-title: Ann Intern Med – volume: 30 start-page: 174 year: 1977 end-page: 181 article-title: Three‐phasic acid/base titration in urine publication-title: Med Lab – volume: 55 start-page: M585 year: 2000 end-page: M592 article-title: Worldwide incidence of hip fracture in elderly women publication-title: Relation to consumption of animal and vegetable foods – volume: 61 start-page: 1181 year: 2006 end-page: 1185 article-title: Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men publication-title: J Gerontol A Biol Sci Med Sci – volume: 26 start-page: 1 year: 1969 end-page: 10 article-title: Chromogens in the creatinine determination of Jaffe [Ueber Chromegene der Keatininbestimmung nach Jaffe] publication-title: Clin Chim Acta – volume: 28 start-page: 1144 year: 1949 end-page: 1162 article-title: Maturation of renal function in childhood publication-title: Clearance Studies – volume: 82 start-page: 522 year: 1993 end-page: 527 article-title: Decreased growth rate of low‐birth‐weight infants with prolonged maximum renal acid stimulation publication-title: Acta Paediatr – volume: 8 start-page: 101 year: 2005 end-page: 109 article-title: Kidney aging publication-title: From phenotype to genetics – volume: 44 start-page: 495 year: 1965 end-page: 506 article-title: Production, excretion, and net balance of fixed acid in patients with renal acidosis publication-title: J Clin Invest – volume: 136 start-page: 1203 year: 2006 end-page: 1208 article-title: Anthropometrics provide a better estimate of urinary organic acid anion excretion than a dietary mineral intake‐based estimate in children, adolescents, and young adults publication-title: J Nutr – volume: 61 start-page: 605 year: 2007 end-page: 609 article-title: Muscularity and adiposity in addition to net acid excretion as predictors of 24‐h urinary pH in young adults and elderly publication-title: Eur J Clin Nutr – volume: 19 start-page: S46 issue: (Suppl 9) year: 2006 end-page: S52 article-title: Renal tubular acidosis publication-title: J Nephrol – volume: 132 start-page: 98 year: 1998 end-page: 104 article-title: Fat oxidation in nonobese and obese adolescents publication-title: Effect of body composition and pubertal development – volume: 83 start-page: 639 year: 2006 end-page: 646 article-title: Longitudinal examination of 24‐h urinary iodine excretion in schoolchildren as a sensitive, hydration status‐independent research tool for studying iodine status publication-title: Am J Clin Nutr – volume: 34 start-page: 969 year: 1955 article-title: Age‐wise standard value for C , C , and Tm in adult males publication-title: J Clin Invest – volume: 4 start-page: 4 year: 1992 end-page: 10 article-title: Predictors of body surface area publication-title: J Clin Anesth – volume: 82 start-page: 1107 year: 2005 end-page: 1114 article-title: Long‐term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children publication-title: Am J Clin Nutr – volume: 82 start-page: 921 year: 2005 end-page: 922 article-title: Dietary protein content and the diet's net acid load publication-title: Opposing effects on bone health – volume: 95 start-page: 791 year: 1995 end-page: 797 article-title: Potential renal acid load of foods and its influence on urine pH publication-title: J Am Diet Assoc – volume: 6 start-page: 28 year: 1969 end-page: 49 article-title: Functional impairment in chronic renal disease. 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| Snippet | OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly... OBJECTIVES: To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly... To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people.... To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly... |
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| Title | Renal Net Acid Excretion Capacity Is Comparable in Prepubescence, Adolescence, and Young Adulthood but Falls with Aging |
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