Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins

• Published in: Blood cancer discovery Vol. 2; no. 4; pp. 388 - 401
• Main Authors: Maimaitiyiming, Yasen, Wang, Qian Qian, Yang, Chang, Ogra, Yasumitsu, Lou, Yinjun, Smith, Clayton A, Hussain, Liaqat, Shao, Yi Ming, Lin, Jiebo, Liu, Jinfeng, Wang, Lingfang, Zhu, Yong, Lou, Haiyan, Huang, Yuan, Li, Xiaoxia, Chang, Kao-Jung, Chen, Hao, Li, Hongyan, Huang, Ying, Tse, Eric, Sun, Jie, Bu, Na, Chiou, Shih-Hwa, Zhang, Yan Fang, Hua, Hao Ying, Ma, Li Ya, Huang, Ping, Ge, Ming Hua, Cao, Feng-Lin, Cheng, Xiaodong, Sun, Hongzhe, Zhou, Jin, Vasliou, Vasilis, Xu, Pengfei, Jin, Jie, Bjorklund, Mikael, Zhu, Hong-Hu, Hsu, Chih-Hung, Naranmandura, Hua
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.07.2021
• Subjects: Humans; Hyperthermia, Induced; Leukemia, Promyelocytic, Acute - drug therapy; Oncogene Proteins, Fusion - genetics; Tretinoin - therapeutic use

The PML/RARα fusion protein is the oncogenic driver in acute promyelocytic leukemia (APL). Although most APL cases are cured by PML/RARα-targeting therapy, relapse and resistance can occur due to drug-resistant mutations. Here we report that thermal stress destabilizes the PML/RARα protein, includin...