Melatonin inhibits paraquat-induced cell death in bovine preimplantation embryos

• Published in: Journal of pineal research Vol. 60; no. 2; pp. 155 - 166
• Main Authors: Pang, Yun-Wei, Sun, Ye-Qing, Sun, Wei-Jun, Du, Wei-Hua, Hao, Hai-Sheng, Zhao, Shan-Jiang, Zhu, Hua-Bin
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2016
• Subjects: Animals; apoptosis; Apoptosis - drug effects; Blastocyst - metabolism; Blastocyst - pathology; Caspase 3 - metabolism; Cattle; embryo; Female; MAP Kinase Signaling System - drug effects; melatonin; Melatonin - pharmacology; oxidative damage; paraquat; Paraquat - adverse effects; Paraquat - pharmacology; Pesticides - adverse effects; Pesticides - pharmacology; Proto-Oncogene Proteins c-bcl-2 - metabolism; X-Linked Inhibitor of Apoptosis Protein - metabolism; apoptosis; embryo; oxidative damage; paraquat; melatonin

Preimplantation embryos are sensitive to oxidative stress‐induced damage that can be caused by reactive oxygen species (ROS) originating from normal embryonic metabolism and/or the external surroundings. Paraquat (PQ), a commonly used pesticide and potent ROS generator, can induce embryotoxicity. Th...