Inherited GATA3 variant associated with positive minimal residual disease in childhood B‐cell acute lymphoblastic leukemia via asparaginase resistance

• Published in: Clinical and translational medicine Vol. 11; no. 8; pp. e507 - n/a
• Main Authors: Li, Chunjie, Liang, Wenyi, He, Yingyi, Zhao, Xinying, Qian, Jiabi, Li, Ziping, Jiang, Chuang, Zheng, Qingqing, Fu, Xiangmeng, Zhang, Weina, Liu, Haiyan, Sun, Xin, Qian, Maoxiang, Zhang, Hui
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley
• Subjects: Asparaginase - genetics; Asparaginase - metabolism; Autophagy; Child; Children & youth; Clinical outcomes; Conflicts of interest; CRISPR; Data analysis; GATA3 Transcription Factor - genetics; GATA3 Transcription Factor - metabolism; Humans; Letter to Editor; Leukemia; Medical prognosis; Neoplasm, Residual; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism

Using an additive logistic regression model, we found that GATA3 rs3824662 A allele and rs3781093 C allele were significantly associated with minimal residual disease (MRD) positivity on day 46 (p = 0.039, odds ratio [OR] = 1.54 [95% confidence interval: 1.01–2.36], and p = 0.036, OR = 1.55 [1.03–2....