n-3 FA increase liver uptake of HDL-cholesterol in mice

• Published in: Lipids Vol. 37; no. 8; pp. 767 - 772
• Main Authors: Morvan, Valérie le, Dumon, Marie-France, Palos-Pinto, Antonio, Bérard, Annie M
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2002; Springer‐Verlag; Springer Nature B.V
• Subjects: adipose tissue; Animals; Blotting, Northern; CD36 Antigens - genetics; CD36 Antigens - metabolism; Cholesterol - blood; Cholesterol Esters - metabolism; Cholesterol, HDL - metabolism; coronary artery disease; Diet; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - pharmacology; Female; females; Fish oils; gene expression; Gene Expression - drug effects; genes; high density lipoprotein cholesterol; humans; lipid peroxidation; lipogenesis; Lipoproteins, HDL - metabolism; liver; Liver - drug effects; Liver - metabolism; Membrane Proteins; Mice; Mice, Inbred C57BL; omega-3 fatty acids; phospholipids; Phospholipids - blood; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; Rodents; Scavenger Receptors, Class B; skeletal muscle; Time Factors; Triglycerides - blood; Tritium

In humans, diets rich in fish oil (containing n-3 FA) decrease the incidence of coronary artery diseases. This is thought to be caused by the induction in liver and skeletal muscle of genes involved in lipid oxidation, and to the repression in liver and adipose tissue of genes responsible for lipoge...