Mating-type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae

• Published in: FEMS yeast research Vol. 6; no. 3; pp. 404 - 413
• Main Authors: Klassen, Roland, Jablonowski, Daniel, Stark, Michael J.R, Schaffrath, Raffael, Meinhardt, Friedhelm
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2006; Oxford University Press
• Subjects: cell cycle; Cell proliferation; Diploids; diploidy; Genes, Mating Type, Fungal; haploidy; Heterozygote; Histone deacetylase; Histone Deacetylase Inhibitors; Histone Deacetylases - genetics; Histone Deacetylases - physiology; killer; Killer Factors, Yeast; Kluyveromyces lactis; Kluyveromyces marxianus var. lactis; linear plasmid; loci; Mating; Mating Factor; Mating types; Mutagenesis, Insertional; Mutants; Mutation; Mycotoxins - toxicity; Peptides - genetics; Peptides - physiology; Pichia; protein subunits; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - physiology; Sexual reproduction; silencing; Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics; Silent Information Regulator Proteins, Saccharomyces cerevisiae - physiology; Sirtuin 2; Sirtuins - genetics; Sirtuins - physiology; Toxins; Yeast; yeasts; zymocin; zymocin; killer; linear plasmid; silencing

Killer-toxin complexes produced by Kluyveromyces lactis and Pichia acaciae inhibit cell proliferation of Saccharomyces cerevisiae. Analysis of their actions in haploid MAT[alpha] cells revealed that introduction of the opposite mating-type locus (MATa) significantly suppressed antizymosis. Together...