Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion

• Published in: Pain (Amsterdam) Vol. 161; no. 11; pp. 2592 - 2602
• Main Authors: Salvo, Elizabeth, Campana, Wendy M., Scheff, Nicole N., Nguyen, Tu Huu, Jeong, Se-hee, Wall, Ian, Wu, Angie K., Zhang, Susanna, Kim, Hyesung, Bhattacharya, Aditi, Janal, Malvin N., Liu, Cheng, Albertson, Donna G., Schmidt, Brian L., Dolan, John C., Schmidt, Robert E., Boada, M. Danilo, Ye, Yi
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.11.2020
• Subjects: Animals; Cancer Pain - etiology; Female; Male; Mice; Mouth Neoplasms - complications; Neoplasm Invasiveness; Peripheral Nerve Injuries - etiology; Peripheral Nerves; Sciatic Nerve

Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied t...