Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion

Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied t...

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Published inPain (Amsterdam) Vol. 161; no. 11; pp. 2592 - 2602
Main Authors Salvo, Elizabeth, Campana, Wendy M., Scheff, Nicole N., Nguyen, Tu Huu, Jeong, Se-hee, Wall, Ian, Wu, Angie K., Zhang, Susanna, Kim, Hyesung, Bhattacharya, Aditi, Janal, Malvin N., Liu, Cheng, Albertson, Donna G., Schmidt, Brian L., Dolan, John C., Schmidt, Robert E., Boada, M. Danilo, Ye, Yi
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer 01.11.2020
Subjects
Animals
Cancer Pain - etiology
Female
Male
Mice
Mouth Neoplasms - complications
Neoplasm Invasiveness
Peripheral Nerve Injuries - etiology
Peripheral Nerves
Sciatic Nerve
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Abstract Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on peripheral nerve physiology and anatomy using a murine sciatic nerve PNI model. Mice with PNI exhibited spontaneous nociception and mechanical allodynia. Perineural invasion induced afterdischarge in A high-threshold mechanoreceptors (HTMRs), mechanical sensitization (ie, decreased mechanical thresholds) in both A and C HTMRs, and mechanical desensitization in low-threshold mechanoreceptors. Perineural invasion resulted in nerve damage, including axon loss, myelin damage, and axon degeneration. Electrophysiological evidence of nerve injury included decreased conduction velocity, and increased percentage of both mechanically insensitive and electrically unexcitable neurons. We conclude that PNI-induced pain is driven by nerve injury and peripheral sensitization in HTMRs.
AbstractList Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on peripheral nerve physiology and anatomy using a murine sciatic nerve PNI model. Mice with PNI exhibited spontaneous nociception and mechanical allodynia. Perineural invasion induced afterdischarge in A high-threshold mechanoreceptors (HTMRs), mechanical sensitization (ie, decreased mechanical thresholds) in both A and C HTMRs, and mechanical desensitization in low-threshold mechanoreceptors. Perineural invasion resulted in nerve damage, including axon loss, myelin damage, and axon degeneration. Electrophysiological evidence of nerve injury included decreased conduction velocity, and increased percentage of both mechanically insensitive and electrically unexcitable neurons. We conclude that PNI-induced pain is driven by nerve injury and peripheral sensitization in HTMRs.
Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on peripheral nerve physiology and anatomy using a murine sciatic nerve PNI model. Mice with PNI exhibited spontaneous nociception and mechanical allodynia. Perineural invasion induced afterdischarge in A high-threshold mechanoreceptors (HTMRs), mechanical sensitization (ie, decreased mechanical thresholds) in both A and C HTMRs, and mechanical desensitization in low-threshold mechanoreceptors. Perineural invasion resulted in nerve damage, including axon loss, myelin damage, and axon degeneration. Electrophysiological evidence of nerve injury included decreased conduction velocity, and increased percentage of both mechanically insensitive and electrically unexcitable neurons. We conclude that PNI-induced pain is driven by nerve injury and peripheral sensitization in HTMRs.Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on peripheral nerve physiology and anatomy using a murine sciatic nerve PNI model. Mice with PNI exhibited spontaneous nociception and mechanical allodynia. Perineural invasion induced afterdischarge in A high-threshold mechanoreceptors (HTMRs), mechanical sensitization (ie, decreased mechanical thresholds) in both A and C HTMRs, and mechanical desensitization in low-threshold mechanoreceptors. Perineural invasion resulted in nerve damage, including axon loss, myelin damage, and axon degeneration. Electrophysiological evidence of nerve injury included decreased conduction velocity, and increased percentage of both mechanically insensitive and electrically unexcitable neurons. We conclude that PNI-induced pain is driven by nerve injury and peripheral sensitization in HTMRs.
Author Wall, Ian
Kim, Hyesung
Bhattacharya, Aditi
Nguyen, Tu Huu
Janal, Malvin N.
Salvo, Elizabeth
Dolan, John C.
Ye, Yi
Campana, Wendy M.
Jeong, Se-hee
Albertson, Donna G.
Wu, Angie K.
Zhang, Susanna
Liu, Cheng
Schmidt, Brian L.
Schmidt, Robert E.
Boada, M. Danilo
Scheff, Nicole N.
AuthorAffiliation Department of Pathology, New York University Langone Medical Center, New York, NY, United States
Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, United States
Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, United States
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States
Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, United States
D.D.S. program, New York University College of Dentistry, New York, NY, United States
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Cites_doi 10.1016/S0301-0082(98)00048-3
10.1016/j.jpain.2007.06.012
10.1016/j.bbr.2005.03.015
10.1097/j.pain.0000000000001044
10.1158/0008-5472.CAN-18-3872
10.1038/nn1992
10.1177/27.10.512319
10.1158/1535-7163.MCT-11-0123
10.1523/JNEUROSCI.21-23-09367.2001
10.1093/bja/aex276
10.3389/fnmol.2017.00284
10.1016/S0006-8993(03)02284-4
10.1136/jnnp.55.4.282
10.1186/2051-5960-2-62
10.1016/j.neuroscience.2017.06.038
10.1016/j.oraloncology.2016.07.016
10.3389/fnint.2018.00052
10.3791/59296-v
10.1523/JNEUROSCI.2399-12.2012
10.1177/1744806919845750
10.1002/9780470942390.mo110116
10.1016/j.jpain.2014.07.003
10.1007/s004019900175
10.1016/j.oraloncology.2014.10.004
10.1523/JNEUROSCI.21-08-j0002.2001
10.3791/58384-v
10.3389/fonc.2019.00434
10.1038/nn.4053
10.1016/j.jpain.2004.09.002
10.1097/j.pain.0000000000000130
10.1038/ncomms8923
10.1007/s12105-016-0722-9
10.1007/978-981-13-1756-9_10
10.1172/JCI82658
10.1371/journal.pone.0207069
10.1097/j.pain.0000000000000492
10.1152/jn.00264.2007
10.1038/nrc.2016.38
10.1016/j.pain.2014.09.030
10.1016/j.brainresrev.2004.07.015
10.1016/j.joms.2020.03.029
10.1126/science.aaf8924
10.5037/jomr.2012.3101
10.1016/j.bbi.2006.12.008
10.1016/j.jpain.2012.01.006
10.1097/j.pain.0000000000001781
10.21873/anticanres.13798
10.1172/JCI58675
10.1002/ana.24017
10.1016/j.neuron.2013.01.030
10.1016/S1474-4422(14)70102-4
10.3389/fnmol.2019.00217
10.1038/ncomms7885
10.1038/nrdp.2017.2
10.1002/stem.1258
10.1097/01.anes.0000286983.33184.9c
10.1016/j.biocel.2006.05.007
10.1523/JNEUROSCI.1600-12.2013
10.1016/j.pain.2012.04.019
10.1523/JNEUROSCI.3388-05.2006
10.1016/j.jns.2013.01.018
10.1016/j.neuron.2006.09.021
10.1152/jn.00506.2014
10.1016/j.heliyon.2019.e01223
10.1097/j.pain.0000000000000365
10.1177/1744806916666841
10.1586/era.12.9
10.1016/j.isci.2019.100760
10.1152/jn.00472.2009
10.1016/j.jpain.2012.05.008
10.1016/j.neuron.2012.02.008
10.3389/fncel.2019.00116
10.1055/s-0036-1571835
10.1038/nn.2407
10.1097/j.pain.0000000000000389
10.1016/j.neuropharm.2018.07.016
10.1212/WNL.46.5.1318
10.1172/JCI86801
10.1097/00005537-200108000-00022
10.1523/JNEUROSCI.5609-07.2008
10.1038/s41598-019-39824-9
10.1016/j.nbd.2013.03.005
10.1016/j.jpain.2012.07.006
10.1038/nrc3131
10.1016/j.oraloncology.2011.08.002
10.1016/j.expneurol.2005.10.028
10.1002/jcb.25300
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Correspondence: Yi Ye, MS, PhD, Bluestone Center for Clinical Research, New York University College of Dentistry, 421 First Avenue, 233W, New York, New York 10010, yy22@nyu.edu, Tel: 212-998-9285, Fax: 212-995-4843
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References Ji (R41-20230818) 2016; 354
Kakigi (R43-20230818) 1992; 55
Macfarlane (R50-20230818) 2012; 3
Wilke (R77-20230818) 2013; 33
Baron (R6-20230818) 2013; 74
Gutierrez (R36-20230818) 2019; 15
Chi (R20-20230818) 2016; 10
Ydens (R81-20230818) 2013; 55
Finnerup (R33-20230818) 2016; 157
Ye (R86-20230818) 2018; 139
Chodroff (R21-20230818) 2016; 12
Reyes-Gibby (R59-20230818) 2014; 15
Jensen (R40-20230818) 2014; 13
Deuis (R27-20230818) 2017; 10
Ein (R31-20230818) 2019; 39
Huyett (R39-20230818) 2017
Sroka (R71-20230818) 2016; 117
Tao (R73-20230818) 2013; 31
Ye (R85-20230818) 2014; 2
Yeh (R88-20230818) 2016; 61
Boada (R11-20230818) 2015; 113
Cai (R16-20230818) 2006; 198
Bakst (R4-20230818) 2016; 77
Li (R48-20230818) 2018; 1099
Mogil (R56-20230818) 2012; 13
Walton (R75-20230818) 1979; 27
Campbell (R19-20230818) 2006; 52
Dalm (R24-20230818) 2015; 156
King (R44-20230818) 2009; 12
Ou (R57-20230818) 2020; 23
Deborde (R25-20230818) 2016; 126
Connelly (R23-20230818) 2004; 5
Fabrizi (R32-20230818) 2000; 100
Boada (R12-20230818) 2020; 161
Boada (R15-20230818) 2008; 28
Menendez (R53-20230818) 2003; 969
Scheff (R64-20230818) 2018; 12
Ye (R83-20230818) 2012; 13
Grayson (R34-20230818) 2019; 9
Wu (R79-20230818) 2018; 13
Binmadi (R9-20230818) 2011; 47
Scheff (R65-20230818) 2017; 158
Ye (R87-20230818) 2010; 103
Bapat (R5-20230818) 2011; 11
Mapplebeck (R51-20230818) 2016; 157
Scheff (R63-20230818) 2019; 12
Ye (R84-20230818) 2011; 10
Djouhri (R30-20230818) 2004; 46
Hua (R38-20230818) 2015; 6
Johnston (R42-20230818) 2012; 12
Ma (R49-20230818) 2011; 121
Amit (R1-20230818) 2016; 16
Wu (R78-20230818) 2001; 21
Boada (R14-20230818) 2007; 98
Sun (R72-20230818) 2018
Quattrone (R58-20230818) 1996; 46
Scholz (R67-20230818) 2007; 10
Wei (R76-20230818) 2019; 13
Bjordal (R10-20230818) 2001; 111
Roh (R60-20230818) 2015; 51
Ye (R82-20230818) 2017; 363
Scanlon (R62-20230818) 2015; 6
Campana (R18-20230818) 2007; 21
Djouhri (R29-20230818) 2006; 26
Lam (R47-20230818) 2012; 32
Smith (R69-20230818) 2017; 119
Colloca (R22-20230818) 2017; 3
Salvo (R61-20230818) 2019; 5
Kolokythas (R45-20230818) 2007; 8
Armati (R2-20230818) 2013; 333
von Hehn (R74-20230818) 2012; 73
McCoy (R52-20230818) 2013; 78
Bennett (R7-20230818) 2012; 13
Minett (R55-20230818) 2011; 1
Green (R35-20230818) 2005; 162
Schmitd (R66-20230818) 2019
Bhatheja (R8-20230818) 2006; 38
Lam (R46-20230818) 2015; 156
Djouhri (R28-20230818) 2012; 153
Shurin (R68-20230818) 2019; 79
Zhang (R89-20230818) 2019; 9
Sorge (R70-20230818) 2015; 18
Boada (R13-20230818) 2014; 155
Deborde (R26-20230818) 2018; 134
Hechler (R37-20230818) 2020
Millan (R54-20230818) 1999; 57
Azam (R3-20230818) 2016; 126
Cain (R17-20230818) 2001; 21
Xiao (R80-20230818) 2007; 107
References_xml – volume: 57
  start-page: 1
  year: 1999
  ident: R54-20230818
  article-title: The induction of pain: an integrative review
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(98)00048-3
– volume: 8
  start-page: 950
  year: 2007
  ident: R45-20230818
  article-title: Validation of the university of California san Francisco oral cancer pain questionnaire
  publication-title: J Pain
  doi: 10.1016/j.jpain.2007.06.012
– volume: 162
  start-page: 90
  year: 2005
  ident: R35-20230818
  article-title: Evidence that tactile stimulation inhibits nociceptive sensations produced by innocuous contact cooling
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2005.03.015
– volume: 158
  start-page: 2396
  year: 2017
  ident: R65-20230818
  article-title: Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000001044
– volume: 79
  start-page: 2736
  year: 2019
  ident: R68-20230818
  article-title: Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-3872
– volume: 10
  start-page: 1361
  year: 2007
  ident: R67-20230818
  article-title: The neuropathic pain triad: neurons, immune cells and glia
  publication-title: Nat Neurosci
  doi: 10.1038/nn1992
– volume: 27
  start-page: 1337
  year: 1979
  ident: R75-20230818
  article-title: Lead asparate, an en bloc contrast stain particularly useful for ultrastructural enzymology
  publication-title: J Histochem Cytochem
  doi: 10.1177/27.10.512319
– volume: 10
  start-page: 1667
  year: 2011
  ident: R84-20230818
  article-title: Nerve growth factor links oral cancer progression, pain, and cachexia
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-11-0123
– volume: 21
  start-page: 9367
  year: 2001
  ident: R17-20230818
  article-title: Functional interactions between tumor and peripheral nerve: changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-23-09367.2001
– volume: 119
  start-page: 705
  year: 2017
  ident: R69-20230818
  article-title: NeuPSIG: investing in solutions to the growing global challenge of neuropathic pain
  publication-title: Br J Anaesth
  doi: 10.1093/bja/aex276
– volume: 10
  start-page: 284
  year: 2017
  ident: R27-20230818
  article-title: Methods used to evaluate pain behaviors in rodents
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2017.00284
– volume: 969
  start-page: 102
  year: 2003
  ident: R53-20230818
  article-title: Initial thermal heat hypoalgesia and delayed hyperalgesia in a murine model of bone cancer pain
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(03)02284-4
– volume: 55
  start-page: 282
  year: 1992
  ident: R43-20230818
  article-title: Mechanisms of pain relief by vibration and movement
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.55.4.282
– volume: 2
  start-page: 62
  year: 2014
  ident: R85-20230818
  article-title: Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/2051-5960-2-62
– volume: 363
  start-page: 50
  year: 2017
  ident: R82-20230818
  article-title: Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2017.06.038
– volume: 61
  start-page: 115
  year: 2016
  ident: R88-20230818
  article-title: Pretreatment pain predicts perineural invasion in oral squamous cell carcinoma: a prospective study
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2016.07.016
– volume: 12
  start-page: 52
  year: 2018
  ident: R64-20230818
  article-title: Neutrophil-mediated endogenous analgesia contributes to sex differences in oral cancer pain
  publication-title: Front Integr Neurosci
  doi: 10.3389/fnint.2018.00052
– year: 2019
  ident: R66-20230818
  article-title: The chick chorioallantoic membrane in vivo model to assess perineural invasion in head and neck cancer
  publication-title: J Vis Exp
  doi: 10.3791/59296-v
– volume: 32
  start-page: 14178
  year: 2012
  ident: R47-20230818
  article-title: Novel animal models of acute and chronic cancer pain: a pivotal role for PAR2
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2399-12.2012
– volume: 15
  start-page: 1744806919845750
  year: 2019
  ident: R36-20230818
  article-title: Tachykinins modulate nociceptive responsiveness and sensitization: in vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice
  publication-title: Mol Pain
  doi: 10.1177/1744806919845750
– volume: 1
  start-page: 383
  year: 2011
  ident: R55-20230818
  article-title: Behavioral measures of pain thresholds
  publication-title: Curr Protoc Mouse Biol
  doi: 10.1002/9780470942390.mo110116
– volume: 15
  start-page: 1015
  year: 2014
  ident: R59-20230818
  article-title: Survival patterns in squamous cell carcinoma of the head and neck: pain as an independent prognostic factor for survival
  publication-title: J Pain
  doi: 10.1016/j.jpain.2014.07.003
– volume: 100
  start-page: 299
  year: 2000
  ident: R32-20230818
  article-title: Focally folded myelin in Charcot-Marie-Tooth neuropathy type 1B with Ser49Leu in the myelin protein zero
  publication-title: Acta Neuropathol
  doi: 10.1007/s004019900175
– volume: 51
  start-page: 16
  year: 2015
  ident: R60-20230818
  article-title: Perineural growth in head and neck squamous cell carcinoma: a review
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2014.10.004
– volume: 21
  start-page: RC140
  year: 2001
  ident: R78-20230818
  article-title: Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-08-j0002.2001
– year: 2018
  ident: R72-20230818
  article-title: A conditioned place preference protocol for measuring incubation of craving in rats
  publication-title: J Vis Exp
  doi: 10.3791/58384-v
– volume: 9
  start-page: 434
  year: 2019
  ident: R89-20230818
  article-title: Integrating clinical and genetic analysis of perineural invasion in head and neck squamous cell carcinoma
  publication-title: Front Oncol
  doi: 10.3389/fonc.2019.00434
– volume: 18
  start-page: 1081
  year: 2015
  ident: R70-20230818
  article-title: Different immune cells mediate mechanical pain hypersensitivity in male and female mice
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4053
– volume: 5
  start-page: 505
  year: 2004
  ident: R23-20230818
  article-title: Evaluation of pain in patients with oral squamous cell carcinoma
  publication-title: J Pain
  doi: 10.1016/j.jpain.2004.09.002
– volume: 134
  start-page: 56857
  year: 2018
  ident: R26-20230818
  article-title: An in vivo murine sciatic nerve model of perineural invasion
  publication-title: J Vis Exp
– volume: 156
  start-page: 923
  year: 2015
  ident: R46-20230818
  article-title: TMPRSS2, a novel membrane-anchored mediator in cancer pain
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000000130
– volume: 6
  start-page: 7923
  year: 2015
  ident: R38-20230818
  article-title: Large-volume en-bloc staining for electron microscopy-based connectomics
  publication-title: Nat Commun
  doi: 10.1038/ncomms8923
– volume: 10
  start-page: 451
  year: 2016
  ident: R20-20230818
  article-title: Interobserver variation among pathologists in evaluating perineural invasion for oral squamous cell carcinoma
  publication-title: Head Neck Pathol
  doi: 10.1007/s12105-016-0722-9
– volume: 1099
  start-page: 115
  year: 2018
  ident: R48-20230818
  article-title: Knowing the neuronal mechanism of spontaneous pain to treat chronic pain in the future
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-981-13-1756-9_10
– volume: 126
  start-page: 1538
  year: 2016
  ident: R25-20230818
  article-title: Schwann cells induce cancer cell dispersion and invasion
  publication-title: J Clin Invest
  doi: 10.1172/JCI82658
– volume: 13
  start-page: e0207069
  year: 2018
  ident: R79-20230818
  article-title: Characterization of sensory neuronal subtypes innervating mouse tongue
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0207069
– volume: 157
  start-page: 1599
  year: 2016
  ident: R33-20230818
  article-title: Neuropathic pain: an updated grading system for research and clinical practice
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000000492
– volume: 98
  start-page: 668
  year: 2007
  ident: R14-20230818
  article-title: Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00264.2007
– volume: 16
  start-page: 399
  year: 2016
  ident: R1-20230818
  article-title: Mechanisms of cancer dissemination along nerves
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc.2016.38
– volume: 155
  start-page: 2646
  year: 2014
  ident: R13-20230818
  article-title: Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats
  publication-title: PAIN
  doi: 10.1016/j.pain.2014.09.030
– volume: 46
  start-page: 131
  year: 2004
  ident: R30-20230818
  article-title: Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
  publication-title: Brain Res Brain Res Rev
  doi: 10.1016/j.brainresrev.2004.07.015
– year: 2020
  ident: R37-20230818
  article-title: Are oral pain and otalgia predictive of perineural invasion in squamous cell carcinoma of the oral tongue?
  publication-title: J Oral Maxill Surg
  doi: 10.1016/j.joms.2020.03.029
– volume: 354
  start-page: 572
  year: 2016
  ident: R41-20230818
  article-title: Pain regulation by non-neuronal cells and inflammation
  publication-title: Science
  doi: 10.1126/science.aaf8924
– volume: 3
  start-page: e1
  year: 2012
  ident: R50-20230818
  article-title: Head and neck cancer pain: systematic review of prevalence and associated factors
  publication-title: J Oral Maxillofac Res
  doi: 10.5037/jomr.2012.3101
– volume: 21
  start-page: 522
  year: 2007
  ident: R18-20230818
  article-title: Schwann cells: activated peripheral glia and their role in neuropathic pain
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2006.12.008
– volume: 13
  start-page: 524
  year: 2012
  ident: R83-20230818
  article-title: Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity
  publication-title: J Pain
  doi: 10.1016/j.jpain.2012.01.006
– volume: 161
  start-page: 949
  year: 2020
  ident: R12-20230818
  article-title: Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000001781
– volume: 39
  start-page: 5933
  year: 2019
  ident: R31-20230818
  article-title: Modulation of BDNF-TRKB interactions on Schwann cell-induced oral squamous cell carcinoma dispersion in vitro
  publication-title: Anticancer Res
  doi: 10.21873/anticanres.13798
– volume: 121
  start-page: 4332
  year: 2011
  ident: R49-20230818
  article-title: Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice
  publication-title: J Clin Invest
  doi: 10.1172/JCI58675
– volume: 74
  start-page: 630
  year: 2013
  ident: R6-20230818
  article-title: Peripheral input and its importance for central sensitization
  publication-title: Ann Neurol
  doi: 10.1002/ana.24017
– volume: 78
  start-page: 138
  year: 2013
  ident: R52-20230818
  article-title: Peptidergic CGRPalpha primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.030
– volume: 13
  start-page: 924
  year: 2014
  ident: R40-20230818
  article-title: Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(14)70102-4
– volume: 12
  start-page: 217
  year: 2019
  ident: R63-20230818
  article-title: Granulocyte-colony stimulating factor-induced neutrophil recruitment provides opioid-mediated endogenous anti-nociception in female mice with oral squamous cell carcinoma
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2019.00217
– volume: 6
  start-page: 6885
  year: 2015
  ident: R62-20230818
  article-title: Galanin modulates the neural niche to favour perineural invasion in head and neck cancer
  publication-title: Nat Commun
  doi: 10.1038/ncomms7885
– volume: 3
  start-page: 17002
  year: 2017
  ident: R22-20230818
  article-title: Neuropathic pain
  publication-title: Nat Rev Dis Primers
  doi: 10.1038/nrdp.2017.2
– volume: 31
  start-page: 83
  year: 2013
  ident: R73-20230818
  article-title: Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain
  publication-title: Stem Cells
  doi: 10.1002/stem.1258
– volume: 107
  start-page: 813
  year: 2007
  ident: R80-20230818
  article-title: Persistent low-frequency spontaneous discharge in A-fiber and C-fiber primary afferent neurons during an inflammatory pain condition
  publication-title: Anesthesiology
  doi: 10.1097/01.anes.0000286983.33184.9c
– volume: 38
  start-page: 1995
  year: 2006
  ident: R8-20230818
  article-title: Schwann cells: origins and role in axonal maintenance and regeneration
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2006.05.007
– volume: 33
  start-page: 507
  year: 2013
  ident: R77-20230818
  article-title: Deconstructing complexity: serial block-face electron microscopic analysis of the hippocampal mossy fiber synapse
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1600-12.2013
– volume: 153
  start-page: 1824
  year: 2012
  ident: R28-20230818
  article-title: Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: possible relationships to aspects of peripheral neuropathic pain and paresthesias
  publication-title: PAIN
  doi: 10.1016/j.pain.2012.04.019
– volume: 26
  start-page: 1281
  year: 2006
  ident: R29-20230818
  article-title: Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3388-05.2006
– volume: 333
  start-page: 68
  year: 2013
  ident: R2-20230818
  article-title: An update on Schwann cell biology—immunomodulation, neural regulation and other surprises
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2013.01.018
– volume: 52
  start-page: 77
  year: 2006
  ident: R19-20230818
  article-title: Mechanisms of neuropathic pain
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.09.021
– volume: 113
  start-page: 100
  year: 2015
  ident: R11-20230818
  article-title: Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00506.2014
– volume: 5
  start-page: e01223
  year: 2019
  ident: R61-20230818
  article-title: Reciprocal interactions between cancer and Schwann cells contribute to oral cancer progression and pain
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2019.e01223
– volume: 156
  start-page: 2562
  year: 2015
  ident: R24-20230818
  article-title: Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000000365
– volume: 12
  start-page: 1744806916666841
  year: 2016
  ident: R21-20230818
  article-title: EXPRESS: BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model
  publication-title: Mol Pain
  doi: 10.1177/1744806916666841
– volume: 12
  start-page: 359
  year: 2012
  ident: R42-20230818
  article-title: Perineural invasion and spread in head and neck cancer
  publication-title: Expert Rev Anticancer Ther
  doi: 10.1586/era.12.9
– volume: 23
  start-page: 100760
  year: 2020
  ident: R57-20230818
  article-title: The general anesthetic isoflurane bilaterally modulates neuronal excitability
  publication-title: iScience
  doi: 10.1016/j.isci.2019.100760
– start-page: 55043
  year: 2017
  ident: R39-20230818
  article-title: A model for perineural invasion in head and neck squamous cell carcinoma
  publication-title: J Vis Exp
– volume: 103
  start-page: 1385
  year: 2010
  ident: R87-20230818
  article-title: Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00472.2009
– volume: 13
  start-page: 921
  year: 2012
  ident: R7-20230818
  article-title: What is spontaneous pain and who has it?
  publication-title: J Pain
  doi: 10.1016/j.jpain.2012.05.008
– volume: 73
  start-page: 638
  year: 2012
  ident: R74-20230818
  article-title: Deconstructing the neuropathic pain phenotype to reveal neural mechanisms
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.02.008
– volume: 13
  start-page: 116
  year: 2019
  ident: R76-20230818
  article-title: Emerging role of Schwann cells in neuropathic pain: receptors, glial mediators and myelination
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2019.00116
– volume: 77
  start-page: 96
  year: 2016
  ident: R4-20230818
  article-title: Mechanisms of perineural invasion
  publication-title: J Neurol Surg B Skull Base
  doi: 10.1055/s-0036-1571835
– volume: 12
  start-page: 1364
  year: 2009
  ident: R44-20230818
  article-title: Unmasking the tonic-aversive state in neuropathic pain
  publication-title: Nat Neurosci
  doi: 10.1038/nn.2407
– volume: 157
  start-page: S2
  issue: suppl 1
  year: 2016
  ident: R51-20230818
  article-title: Sex differences in pain: a tale of two immune cells
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000000389
– volume: 139
  start-page: 182
  year: 2018
  ident: R86-20230818
  article-title: Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2018.07.016
– volume: 46
  start-page: 1318
  year: 1996
  ident: R58-20230818
  article-title: Autosomal recessive hereditary motor and sensory neuropathy with focally folded myelin sheaths: clinical, electrophysiologic, and genetic aspects of a large family
  publication-title: Neurology
  doi: 10.1212/WNL.46.5.1318
– volume: 126
  start-page: 1242
  year: 2016
  ident: R3-20230818
  article-title: Cancer's got nerve: Schwann cells drive perineural invasion
  publication-title: J Clin Invest
  doi: 10.1172/JCI86801
– volume: 111
  start-page: 1440
  year: 2001
  ident: R10-20230818
  article-title: A prospective study of quality of life in head and neck cancer patients. Part II: longitudinal data
  publication-title: Laryngoscope
  doi: 10.1097/00005537-200108000-00022
– volume: 28
  start-page: 2006
  year: 2008
  ident: R15-20230818
  article-title: Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5609-07.2008
– volume: 9
  start-page: 4574
  year: 2019
  ident: R34-20230818
  article-title: Depiction of oral tumor-induced trigeminal afferent responses using single-fiber electrophysiology
  publication-title: Scientific Rep
  doi: 10.1038/s41598-019-39824-9
– volume: 55
  start-page: 95
  year: 2013
  ident: R81-20230818
  article-title: The neuroinflammatory role of Schwann cells in disease
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2013.03.005
– volume: 13
  start-page: 932
  year: 2012
  ident: R56-20230818
  article-title: The etiology and symptomatology of spontaneous pain
  publication-title: J Pain
  doi: 10.1016/j.jpain.2012.07.006
– volume: 11
  start-page: 695
  year: 2011
  ident: R5-20230818
  article-title: Perineural invasion and associated pain in pancreatic cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3131
– volume: 47
  start-page: 1005
  year: 2011
  ident: R9-20230818
  article-title: Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2011.08.002
– volume: 198
  start-page: 65
  year: 2006
  ident: R16-20230818
  article-title: Early paranodal myelin swellings (tomacula) in an avian riboflavin deficiency model of demyelinating neuropathy
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2005.10.028
– volume: 117
  start-page: 491
  year: 2016
  ident: R71-20230818
  article-title: Schwann cells increase prostate and pancreatic tumor cell invasion using laminin binding A6 integrin
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.25300
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Snippet Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater...
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SubjectTerms Animals
Cancer Pain - etiology
Female
Male
Mice
Mouth Neoplasms - complications
Neoplasm Invasiveness
Peripheral Nerve Injuries - etiology
Peripheral Nerves
Sciatic Nerve
Title Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00006396-202011000-00016
https://www.ncbi.nlm.nih.gov/pubmed/32658150
https://www.proquest.com/docview/2423515832
https://pubmed.ncbi.nlm.nih.gov/PMC7572698
Volume 161
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