PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial - Fiore, Daniela; Gianfrilli, Daniele; Giannetta, Elisa; Galea, Nicola; Panio, Giuseppe; di Dato, Carla; Pofi, Riccardo; Pozza, Carlotta; Sbardella, Emilia; Carbone, Iacopo; Naro, Fabio; Lenzi, Andrea; et al. (The journal of clinical endocrinology and metabolism, 2016)
Keywords: Adipose tissue; Adiposity - drug effects; Adiposity - genetics; Adult; Aged; Animal models; Animals; Biopsy; Body fat; Cardiomyocytes; Cardiovascular diseases; Cell culture; Cyclic Nucleotide Phosphodiesterases, Type 5 - chemistry; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - physiopathology; DNA microarrays; Double-Blind Method; Flow Cytometry; Gene expression; Heart; Humans; Inflammation; Magnetic resonance imaging; Male; Mice; Mice, Obese; MicroRNAs; MicroRNAs - genetics; Middle Aged; miRNA; Obesity, Abdominal - drug therapy; Obesity, Abdominal - metabolism; Obesity, Abdominal - pathology; Phosphodiesterase 5 Inhibitors - pharmacology; Placebos; Real-Time Polymerase Chain Reaction; Sildenafil; Sildenafil Citrate - pharmacology; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism