Phenotypic variability in human skin mast cells

• Published in: Experimental dermatology Vol. 25; no. 6; pp. 434 - 439
• Main Authors: Babina, Magda, Guhl, Sven, Artuc, Metin, Trivedi, Neil N., Zuberbier, Torsten
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.06.2016
• Subjects: Adolescent; Biological Variation, Population; Child; Child, Preschool; chymase; degranulation; histamine; Histamine - analysis; Humans; IgE receptor; Infant; Infant, Newborn; Male; mast cells; Mast Cells - chemistry; Mast Cells - cytology; Mast Cells - enzymology; Proto-Oncogene Proteins c-kit - analysis; Receptors, IgE - analysis; Skin - cytology; tryptase; IgE receptor; histamine; degranulation; mast cells; tryptase; chymase

Mast cells (MCs) are unique constituents of the human body. While inter‐individual differences may influence the ways by which MCs operate in their skin habitat, they have not been surveyed in a comprehensive manner so far. We therefore set out to quantify skin MC variability in a large cohort of su...