Developmental control via GATA factor interplay at chromatin domains

• Published in: Journal of cellular physiology Vol. 205; no. 1; pp. 1 - 9
• Main Authors: Bresnick, Emery H., Martowicz, Melissa L., Pal, Saumen, Johnson, Kirby D.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2005
• Subjects: Animals; Cell Differentiation; Chromatin - chemistry; Chromatin - genetics; Chromatin - metabolism; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Erythroid-Specific DNA-Binding Factors; Hematopoiesis; Humans; Models, Biological; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism

Despite the extraordinary task of packaging mammalian DNA within the constraints of a cell nucleus, individual genes assemble into cell type‐specific chromatin structures with high fidelity. This chromatin architecture is a crucial determinant of gene expression signatures that distinguish specific...