Effects of Exogenous Glucagon-Like Peptide-1 on the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 99; no. 12; pp. E2628 - E2634
• Main Authors: Trahair, Laurence G., Horowitz, Michael, Hausken, Trygve, Feinle-Bisset, Christine, Rayner, Christopher K., Jones, Karen L.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2014; Copyright by The Endocrine Society
• Subjects: Aged; Autonomic Nervous System - drug effects; Blood flow; Blood Glucose - metabolism; Blood pressure; Blood Pressure - drug effects; Cardiovascular system; Clinical trials; Double-Blind Method; Duodenum - metabolism; Fasting; Female; Gastric emptying; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - pharmacology; Glucose; Glucose - administration & dosage; Glucose - pharmacology; Heart rate; Heart Rate - drug effects; Humans; Insulin - blood; Intubation, Gastrointestinal; Male; Mesenteric Arteries - drug effects; Peptides; Splanchnic Circulation - drug effects

Context:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).Objective:To determine whether exogenous GLP-1 modulates the effec...