Effects of Exogenous Glucagon-Like Peptide-1 on the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects

Context:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).Objective:To determine whether exogenous GLP-1 modulates the effec...

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Published inThe journal of clinical endocrinology and metabolism Vol. 99; no. 12; pp. E2628 - E2634
Main Authors Trahair, Laurence G., Horowitz, Michael, Hausken, Trygve, Feinle-Bisset, Christine, Rayner, Christopher K., Jones, Karen L.
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.12.2014
Copyright by The Endocrine Society
Subjects
Aged
Autonomic Nervous System - drug effects
Blood flow
Blood Glucose - metabolism
Blood pressure
Blood Pressure - drug effects
Cardiovascular system
Clinical trials
Double-Blind Method
Duodenum - metabolism
Fasting
Female
Gastric emptying
Glucagon
Glucagon-like peptide 1
Glucagon-Like Peptide 1 - pharmacology
Glucose
Glucose - administration & dosage
Glucose - pharmacology
Heart rate
Heart Rate - drug effects
Humans
Insulin - blood
Intubation, Gastrointestinal
Male
Mesenteric Arteries - drug effects
Peptides
Splanchnic Circulation - drug effects
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Abstract Context:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).Objective:To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.Design:A double-blind randomized trial was conducted.Setting:Community-dwelling residents attended a clinical research laboratory.Patients:Ten healthy “older” subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.Interventions:Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = −30–60 min). Between t = 0–60 min, ID glucose was infused at 3 kcal/min.Main Outcome Measures:BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.Results:During the fasting period (t = −30–0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0–60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).Conclusions:In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
AbstractList Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).CONTEXTStudies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.OBJECTIVETo determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.A double-blind randomized trial was conducted.DESIGNA double-blind randomized trial was conducted.Community-dwelling residents attended a clinical research laboratory.SETTINGCommunity-dwelling residents attended a clinical research laboratory.Ten healthy "older" subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.PATIENTSTen healthy "older" subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min.INTERVENTIONSIntravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min.BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.MAIN OUTCOME MEASURESBP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.During the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).RESULTSDuring the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.CONCLUSIONSIn healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects. A double-blind randomized trial was conducted. Community-dwelling residents attended a clinical research laboratory. Ten healthy "older" subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied. Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min. BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured. During the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05). In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
Context:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).Objective:To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.Design:A double-blind randomized trial was conducted.Setting:Community-dwelling residents attended a clinical research laboratory.Patients:Ten healthy “older” subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.Interventions:Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = −30–60 min). Between t = 0–60 min, ID glucose was infused at 3 kcal/min.Main Outcome Measures:BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.Results:During the fasting period (t = −30–0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0–60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).Conclusions:In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
CONTEXT:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). OBJECTIVE:To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects. DESIGN:A double-blind randomized trial was conducted. SETTING:Community-dwelling residents attended a clinical research laboratory. PATIENTS:Ten healthy “older” subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied. INTERVENTIONS:Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = −30–60 min). Between t = 0–60 min, ID glucose was infused at 3 kcal/min. MAIN OUTCOME MEASURES:BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured. RESULTS:During the fasting period (t = −30–0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0–60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05). CONCLUSIONS:In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
Author Rayner, Christopher K.
Jones, Karen L.
Horowitz, Michael
Hausken, Trygve
Trahair, Laurence G.
Feinle-Bisset, Christine
AuthorAffiliation Discipline of Medicine (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; National Health and Medical Research Council Centre of Research Excellence in Translating Nutritional Science to Good Health (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; and Section for Gastroenterology (T.H.), Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway
AuthorAffiliation_xml – name: Discipline of Medicine (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; National Health and Medical Research Council Centre of Research Excellence in Translating Nutritional Science to Good Health (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia; and Section for Gastroenterology (T.H.), Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway
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  givenname: Laurence G.
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  organization: 1Discipline of Medicine (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia
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  givenname: Christopher K.
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  email: karen.jones@adelaide.edu.au
  organization: 1Discipline of Medicine (L.G.T., M.H., C.F.-B., C.K.R., K.L.J.), The University of Adelaide, Adelaide 5005, Australia
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Snippet Context:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated...
CONTEXT:Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated...
Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between...
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SubjectTerms Aged
Autonomic Nervous System - drug effects
Blood flow
Blood Glucose - metabolism
Blood pressure
Blood Pressure - drug effects
Cardiovascular system
Clinical trials
Double-Blind Method
Duodenum - metabolism
Fasting
Female
Gastric emptying
Glucagon
Glucagon-like peptide 1
Glucagon-Like Peptide 1 - pharmacology
Glucose
Glucose - administration & dosage
Glucose - pharmacology
Heart rate
Heart Rate - drug effects
Humans
Insulin - blood
Intubation, Gastrointestinal
Male
Mesenteric Arteries - drug effects
Peptides
Splanchnic Circulation - drug effects
Title Effects of Exogenous Glucagon-Like Peptide-1 on the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects
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