Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression

• Published in: Journal of cellular physiology Vol. 213; no. 2; pp. 374 - 383
• Main Authors: Hugo, Honor, Ackland, M. Leigh, Blick, Tony, Lawrence, Mitchell G., Clements, Judith A., Williams, Elizabeth D., Thompson, Erik W.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2007
• Subjects: Biomarkers - metabolism; Breast Neoplasms; Carcinoma - pathology; Carcinoma - physiopathology; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Epithelial Cells - cytology; Epithelial Cells - metabolism; Epithelium - pathology; Epithelium - physiology; Female; Humans; Male; Mesoderm - pathology; Mesoderm - physiology; Neoplasm Invasiveness; Prostatic Neoplasms - pathology; Prostatic Neoplasms - physiopathology

Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death—metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the...